Skip to main content
Fig. 3 | BMC Nephrology

Fig. 3

From: Bioinformatics analysis of proteomics profiles in senescent human primary proximal tubule epithelial cells

Fig. 3

Biological functions including translation elongation, stress and glycolysis could mediate the senescence-cell activities by acting on cytoskeleton regulation. The molecular network of DEPs was built by protein-protein interactions. In the network, RPS8, ETF1, EEF1A1, and EEF2 regulate eukaryotic translation elongation (Color: yellow), TKT, GAPDH, ALDOA, ENO2, LDHA, and PKLR are involved in glycolysis (Color: blue), DEPs, such as ACTN2, VIM, ANXA2, MSN, and GSM mediate cytoskeleton regulation (Color: red). CANX, HSP90B1, HSP90AA1 and HYOU1 are associated with oxidative stress (Color: green). Translation elongation, stress, glycolysis were all act on the cytoskeleton regulation, and in turn regulate cell activities in senescent PTEC (Red up arrow meant DEPs upregulated in P6, and blue down arrow meant DEPs downregulated in P6)

Back to article page