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Table 1 The downregulated DEPs in P6 tubule cells detected by LC-MS (fold change >1.5)

From: Bioinformatics analysis of proteomics profiles in senescent human primary proximal tubule epithelial cells

Accession

Description

Protein

P6/P3 ratio

Standard deviation

NP_001074007.2

aldo keto reductase family 1 member B15

AKR1B15

0.01

0.006

NP_001002858.1

annexin A2

ANXA2

0.12

0.025

NP_001619.1

aldose reductase

AKR1B1

0.17

0.026

XP_933678.1

PREDICTED POTE ankyrin domain family member I

POTEI

0.18

0.15

NP_002037.2

glyceraldehyde 3 phosphate dehydrogenase

GAPDH

0.30

0.03

NP_000289.1

pyruvate kinase isozymes R L

PKLR

0.37

0.016

NP_003290.1

endoplasmin precursor

HSP90B1

0.41

0.006

NP_002256.2

importin subunit beta 1

KPNB1

0.41

0.02

NP_003325.2

ubiquitin like modifier activating enzyme 1

UBA1

0.43

0.007

NP_005339.3

heat shock protein HSP 90 alpha

HSP90AA2

0.44

0.004

NP_001153706.1

sodium potassium transporting ATPase subunit alpha 1

ATP1A1

0.48

0.019

NP_001171651.1

glucose 6 phosphate isomerase

GPI

0.61

0.009

NP_001393.1

elongation factor 1 alpha 1

EEF1A1

0.66

0.009

NP_945189.1

protein glutamine gamma glutamyltransferase 2

TGM2

0.63

0.017

NP_065843.3

neutral cholesterol ester hydrolase 1

AADACL1

P3

 

NP_000687.3

4 trimethylaminobutyraldehyde dehydrogenase

ALDH9A1

P3

 

NP_004299.1

rho GTPase activating protein 1

ARHGAP1

P3

 

NP_001719.2

basigin precursor

BSG

P3

 

NP_001019820.1

calnexin precursor

CANX

P3

 

NP_006575.2

T complex protein 1 subunit zeta 2

CCT6B

P3

 

NP_002942.2

dolichyl diphosphooligosaccharide protein glycosyltransferase subunit 2 precursor

DDOST

P3

 

NP_004721.1

eukaryotic peptide chain release factor subunit 1

ETF1

P3

 

NP_110416.1

minor histocompatibility antigen H13

HM13

P3

 

NP_006380.1

hypoxia up regulated protein 1 precursor

HYOU1

P3

 

NP_005557.1

L lactate dehydrogenase A chain

LDHA

P3

 

NP_001244303.1

lamin

LMNA

P3

 

NP_000894.1

NADPH dehydrogenase quinone 1

NQO1

P3

 

NP_005023.2

plastin 3

PLS3

P3

 

NP_006397.1

peroxiredoxin 4 precursor

PRDX4

P3

 

NP_001096137.1

proteasome subunit alpha type 4

PSMA4

P3

 

NP_653263.2

proteasome subunit alpha type 7 like

PSMA7

P3

 

NP_055205.2

staphylococcal nuclease domain containing protein 1

SND1

P3

 

NP_110437.2

thioredoxin domain containing protein 5 precursor

TXNDC5

P3

 

NP_066964.1

X ray repair cross complementing protein 5

XRCC5

P3