From: Changes in renal WT-1 expression preceding hypertension development
Strain | 0-week-old rat | 1-week-old rat | 2-week-old rat | 3-week-old rat | 4-week-old rat | 5-week-old rat | 6-week-old rat | 7-week-old rat | 8-week-old rat |
---|---|---|---|---|---|---|---|---|---|
SHR | |||||||||
Body weight (g) | 6 ± 1 | 13 ± 3 | 24 ± 4 | 45 ± 6 | 82 ± 7 | 100 ± 10 | 130 ± 9* | 150 ± 9* | 160 ± 10* |
WKY | |||||||||
Body weight (g) | 7 ± 1 | 17 ± 4 | 29 ± 5 | 54 ± 7 | 92 ± 8 | 115 ± 9 | 150 ± 8 | 175 ± 10 | 190 ± 12 |
SHR | |||||||||
Renal/Body weight (mg/g) | 5.60 ± 0.3 | 6.05 ± 0.90 | 5.9 ± 1.00 | 5.86 ± 0.90 | 6.02 ± 1.10 | 7 ± 1.30 | 7.7 ± 1.00 | 7.5 ± 1.20 | 8 ± 1.20 |
WKY | |||||||||
Renal/Body weight (mg/g) | 6.1 ± 0.30 | 7.43 ± 1.10 | 6.66 ± 1.10 | 6.9 ± 1.20 | 6.82 ± 1.20 | 6.3 ± 1.20 | 7.3 ± 1.10 | 6.7 ± 1.10 | 7.3 ± 1.10 |
SHR | |||||||||
SBP (mmHg) | ------- | ------- | ------- | ------- | 142 ± 11 | 150 ± 10 | 195 ± 10** | 230 ± 15** | 250 ± 20** |
WKY | |||||||||
SBP (mmHg) | ------- | ------- | ------- | ------- | 135 ± 8 | 140 ± 7 | 145 ± 8 | 148 ± 7 | 150 ± 10 |