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Fig. 5 | BMC Nephrology

Fig. 5

From: Mesangial cells from patients with IgA nephropathy have increased susceptibility to galactose-deficient IgA1

Fig. 5

Release of CCL5, IL-8 and MCP-1. Mesangial cells (MCs) from patients with IgA nephropathy (IgAN) and controls were stimulated with IgA1 purified from blood from healthy controls (cIgA) or patients with IgAN (gd-IgA) or medium only for 24 h and the release of cytokines into the medium was investigated. Stimulation of control MCs and IgAN MCs with gd-IgA resulted in an increased release of CCL5 in both groups of cells, in contrast stimulation with cIgA did not affect either group of cells at all (a). Only the control MCs responded to treatment with gd-IgA with an increased release of IL-8 (b) and MCP-1 (c). Grey bars represent control MCs, black bars represent IgAN MCs * P < 0.05, ** P < 0.01, ***P < 0.001, error bars represent SEM

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