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Table 1 Basal biochemistry and echocardiography

From: Gas6 protein: its role in cardiovascular calcification

  8–9 weeks old, healthy 34–36 weeks old, healthy
Parameter C57BL/6 Gas6-/- C57BL/6 Gas6-/-
Body weight [g] 20.2 ± 0.7 18.6 ± 1.6 30.1 ± 6.4 26.4 ± 4.2
Serum parameter     
 Urea [mmol/l] 10.8 ± 3.3 11.6 ± 1.9 6.6 ± 1 6.0 ± 0.9
 Creatinine [μmol/l] 19.6 ± 2.1 24.5 ± 8.6 18.0 ± 5.9 26.2 ± 16.7
 Calcium [mmol/l] 2.48 ± 0.10 2.23 ± 0.08 2.39 ± 0.13 2.39 ± 0.09
 Phosphate [mmol/l] 3.11 ± 0.91 3.05 ± 0.82 2.88 ± 0.45 2.85 ± 0.34
 Protein [g/dl] 4.46 ± 0.74 4.90 ± 0.15 6.00 ± 0.42 5.50 ± 0.26*
 Alkaline phosphatase [U/l] 255 ± 106 256 ± 35 142 ± 54 207 ± 69
 ucMGP [nM] 3158 ± 458 2987 ± 554 3523 ± 1645 3532 ± 1095
 Protein S [ng/ml] 0.97 ± 0.24 0.87 ± 0.16 0.80 ± 0.14 0.72 ± 0.14
Echocardiography     
 Left ventricular mass [mg] 50.8 ± 11.4 73.6 ± 9.8* 98.6 ± 15.2 81.8 ± 29.5
 Stroke volume [μl] 23.9 ± 9.0 20.3 ± 6.3 23.6 ± 6.2 19.8 ± 4.3
 Ejection Fraction [%] 54.3 ± 11 45.6 ± 7.8 40.1 ± 9.6 41.5 ± 11.0
 VACC [mm/ms] 2.09 ± 0.98 2.06 ± 1.15 2.13 ± 1.52 1.72 ± 0.72
  1. Baseline biochemical and functional characteristics of healthy wildtype and Gas6-/- mice at different ages (Mean ± SD), ucMGP uncarboxylated matrix Gla protein, V ACC pulse-wave velocity over the common carotid artery, WT wildtype *p < 0.05 to corresponding wildtype control
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