From: Gas6 protein: its role in cardiovascular calcification
Parameter | C57BL\6 | Gas6-/- | ||||
---|---|---|---|---|---|---|
Model | Warfarin | UniNx | Electrocautery | Warfarin | UniNx | Electrocautery |
Body weight [g] | 22.9 ± 1.6 | 24.4 ± 2.2*** | 22.3 ± 1.6 | 19.1 ± 1.7 | 19.1 ± 3.2* | 18.5 ± 3.0 |
Serum parameter | ||||||
Urea [mmol/l] | 6.27 ± 0.63*** | 10.26 ± 3.58 | 10.58 ± 1.62 | 6.43 ± 1.29 | 10.25 ± 2.56 | 17.1 ± 11.58 |
Creatinine [μmol/l] | 22.0 ± 1.7 | 25.1 ± 2.4**** | 30.3 ± 3.7**** | 23.6 ± 6.32 | 29.9 ± 14 | 30.3 ± 3.8 |
Calcium [mmol/l] | 2.58 ± 0.09 | 2.50 ± 0.12 | 2.73 ± 0.14*** | 2.67 ± 0.17 | 2.50 ± 0.12 | 2.84 ± 0.27*** |
Phosphate [mmol/l] | 2.84 ± 0.22 | 2.78 ± 0.29 | 2.90 ± 0.30 | 3.68 ± 0.60 | 3.47 ± 0.89 | 3.91 ± 0.68 |
Protein [g/dL] | 6.58 ± 0.38*** | 5.74 ± 0.74**** | 5.47 ± 0.49*** | 6.03 ± 0.32*** | 5.70 ± 0.31*** | 5.41 ± 0.55 |
Alkaline phosphatase [U/l] | 205 ± 27 | 173 ± 65 | 166 ± 36 | 228 ± 46 | 201 ± 64 | 187 ± 74 |
ucMGP [nM] | 5374 ± 1368 | 4369 ± 855 | 3810 ± 1283 | 5963 ± 2612 | 4903 ± 1688 | 4970 ± 489 |
Protein S [ng/ml] | 1.05 ± 0.19 | 0.80 ± 0.12 | 0.72 ± 0.03 | 0.83 ± 0.24 | 0.83 ± 0.23 | 0.83 ± 0.27 |
Echocardiography | ||||||
Left ventricular mass [mg] | 79.0 ± 22 | 60.7 ± 15 | 59.1 ± 12 | 69.2 ± 14.7 | 74.1 ± 28.5 | 61.4 ± 16.6 |
Stroke volume [μl] | 22.0 ± 6.0 | 13.4 ± 2.7 | 10.4 ± 2.8 | 20.6 ± 4.3 | 24.4 ± 8.9 | 10.2 ± 6.2 |
Ejection Fraction [%] | 46.6 ± 11.6 | 33.3 ± 13.8 | 33.7 ± 7.4 | 44.8 ± 2.6 | 58.4 ± 21* | 38.4 ± 18 |
VACC [mm/ms] | 1.97 ± 0.71 | 2.69 ± 1.01 | 1.78 ± 0.46 | 2.26 ± 2.14 | 3.03 ± 1.38 | 1.98 ± 0.37 |
24 h urine | ||||||
GFR [μL/min] | 76.9 ± 36.9 | 55.2 ± 32.4 | 41.7 ± 21.3 | 56.6 ± 32.8 | 41.6 ± 28.1 | 40.4 ± 13.0 |
Protein [mg/dl] | 26. ± 17 | 13 ± 4.6*** | 6.7 ± 1.9*** | 14.0 ± 4.9 | 9.5 ± 6*** | 17.7 ± 4.2 |
Creatinine [μmol/l] | 2071 ± 2005 | 3853 ± 2520 | 3062 ± 1133 | 4283 ± 3853 | 2175 ± 667 | 914 ± 179 |