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Table 2 Final biochemistry and echocardiography

From: Gas6 protein: its role in cardiovascular calcification

Parameter

C57BL\6

Gas6-/-

Model

Warfarin

UniNx

Electrocautery

Warfarin

UniNx

Electrocautery

Body weight [g]

22.9 ± 1.6

24.4 ± 2.2***

22.3 ± 1.6

19.1 ± 1.7

19.1 ± 3.2*

18.5 ± 3.0

Serum parameter

      

 Urea [mmol/l]

6.27 ± 0.63***

10.26 ± 3.58

10.58 ± 1.62

6.43 ± 1.29

10.25 ± 2.56

17.1 ± 11.58

 Creatinine [μmol/l]

22.0 ± 1.7

25.1 ± 2.4****

30.3 ± 3.7****

23.6 ± 6.32

29.9 ± 14

30.3 ± 3.8

 Calcium [mmol/l]

2.58 ± 0.09

2.50 ± 0.12

2.73 ± 0.14***

2.67 ± 0.17

2.50 ± 0.12

2.84 ± 0.27***

 Phosphate [mmol/l]

2.84 ± 0.22

2.78 ± 0.29

2.90 ± 0.30

3.68 ± 0.60

3.47 ± 0.89

3.91 ± 0.68

 Protein [g/dL]

6.58 ± 0.38***

5.74 ± 0.74****

5.47 ± 0.49***

6.03 ± 0.32***

5.70 ± 0.31***

5.41 ± 0.55

 Alkaline phosphatase [U/l]

205 ± 27

173 ± 65

166 ± 36

228 ± 46

201 ± 64

187 ± 74

 ucMGP [nM]

5374 ± 1368

4369 ± 855

3810 ± 1283

5963 ± 2612

4903 ± 1688

4970 ± 489

 Protein S [ng/ml]

1.05 ± 0.19

0.80 ± 0.12

0.72 ± 0.03

0.83 ± 0.24

0.83 ± 0.23

0.83 ± 0.27

Echocardiography

      

 Left ventricular mass [mg]

79.0 ± 22

60.7 ± 15

59.1 ± 12

69.2 ± 14.7

74.1 ± 28.5

61.4 ± 16.6

 Stroke volume [μl]

22.0 ± 6.0

13.4 ± 2.7

10.4 ± 2.8

20.6 ± 4.3

24.4 ± 8.9

10.2 ± 6.2

 Ejection Fraction [%]

46.6 ± 11.6

33.3 ± 13.8

33.7 ± 7.4

44.8 ± 2.6

58.4 ± 21*

38.4 ± 18

 VACC [mm/ms]

1.97 ± 0.71

2.69 ± 1.01

1.78 ± 0.46

2.26 ± 2.14

3.03 ± 1.38

1.98 ± 0.37

24 h urine

      

 GFR [μL/min]

76.9 ± 36.9

55.2 ± 32.4

41.7 ± 21.3

56.6 ± 32.8

41.6 ± 28.1

40.4 ± 13.0

 Protein [mg/dl]

26. ± 17

13 ± 4.6***

6.7 ± 1.9***

14.0 ± 4.9

9.5 ± 6***

17.7 ± 4.2

 Creatinine [μmol/l]

2071 ± 2005

3853 ± 2520

3062 ± 1133

4283 ± 3853

2175 ± 667

914 ± 179

  1. *p < 0.05 to corresponding wildtype group *** p < 0.05 to healthy control group ****p < 0.001 to healthy control group
  2. Biochemical and functional characteristics of wildtype and Gas6-/- after 8 weeks of treatment (Mean ± SD), GFR glomerular filtration rate, ucMGP uncarboxylated matrix Gla protein, UniNx uninephrectomy, VACC pulse-wave velocity over the arteria carotis communis)