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Table 2 Final biochemistry and echocardiography

From: Gas6 protein: its role in cardiovascular calcification

Parameter C57BL\6 Gas6-/-
Model Warfarin UniNx Electrocautery Warfarin UniNx Electrocautery
Body weight [g] 22.9 ± 1.6 24.4 ± 2.2*** 22.3 ± 1.6 19.1 ± 1.7 19.1 ± 3.2* 18.5 ± 3.0
Serum parameter       
 Urea [mmol/l] 6.27 ± 0.63*** 10.26 ± 3.58 10.58 ± 1.62 6.43 ± 1.29 10.25 ± 2.56 17.1 ± 11.58
 Creatinine [μmol/l] 22.0 ± 1.7 25.1 ± 2.4**** 30.3 ± 3.7**** 23.6 ± 6.32 29.9 ± 14 30.3 ± 3.8
 Calcium [mmol/l] 2.58 ± 0.09 2.50 ± 0.12 2.73 ± 0.14*** 2.67 ± 0.17 2.50 ± 0.12 2.84 ± 0.27***
 Phosphate [mmol/l] 2.84 ± 0.22 2.78 ± 0.29 2.90 ± 0.30 3.68 ± 0.60 3.47 ± 0.89 3.91 ± 0.68
 Protein [g/dL] 6.58 ± 0.38*** 5.74 ± 0.74**** 5.47 ± 0.49*** 6.03 ± 0.32*** 5.70 ± 0.31*** 5.41 ± 0.55
 Alkaline phosphatase [U/l] 205 ± 27 173 ± 65 166 ± 36 228 ± 46 201 ± 64 187 ± 74
 ucMGP [nM] 5374 ± 1368 4369 ± 855 3810 ± 1283 5963 ± 2612 4903 ± 1688 4970 ± 489
 Protein S [ng/ml] 1.05 ± 0.19 0.80 ± 0.12 0.72 ± 0.03 0.83 ± 0.24 0.83 ± 0.23 0.83 ± 0.27
Echocardiography       
 Left ventricular mass [mg] 79.0 ± 22 60.7 ± 15 59.1 ± 12 69.2 ± 14.7 74.1 ± 28.5 61.4 ± 16.6
 Stroke volume [μl] 22.0 ± 6.0 13.4 ± 2.7 10.4 ± 2.8 20.6 ± 4.3 24.4 ± 8.9 10.2 ± 6.2
 Ejection Fraction [%] 46.6 ± 11.6 33.3 ± 13.8 33.7 ± 7.4 44.8 ± 2.6 58.4 ± 21* 38.4 ± 18
 VACC [mm/ms] 1.97 ± 0.71 2.69 ± 1.01 1.78 ± 0.46 2.26 ± 2.14 3.03 ± 1.38 1.98 ± 0.37
24 h urine       
 GFR [μL/min] 76.9 ± 36.9 55.2 ± 32.4 41.7 ± 21.3 56.6 ± 32.8 41.6 ± 28.1 40.4 ± 13.0
 Protein [mg/dl] 26. ± 17 13 ± 4.6*** 6.7 ± 1.9*** 14.0 ± 4.9 9.5 ± 6*** 17.7 ± 4.2
 Creatinine [μmol/l] 2071 ± 2005 3853 ± 2520 3062 ± 1133 4283 ± 3853 2175 ± 667 914 ± 179
  1. *p < 0.05 to corresponding wildtype group *** p < 0.05 to healthy control group ****p < 0.001 to healthy control group
  2. Biochemical and functional characteristics of wildtype and Gas6-/- after 8 weeks of treatment (Mean ± SD), GFR glomerular filtration rate, ucMGP uncarboxylated matrix Gla protein, UniNx uninephrectomy, VACC pulse-wave velocity over the arteria carotis communis)
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