Skip to main content

Table 2 Patient characteristics in patients with diabetes mellitus and CKD across different antidiabetic treatment regimens

From: Glycaemic control and antidiabetic therapy in patients with diabetes mellitus and chronic kidney disease – cross-sectional data from the German Chronic Kidney Disease (GCKD) cohort

 

Dietary treatment

Oral anti-diabetic drugs alone, any

Oral anti-diabetic drugs plus insulin

Insulin alone

P-value a

Classes of oral antidiabetic drugs, alone or in combination

Metformin

Sulfonyl-ureas

Glinides

DPP-4-inhibitors

Number

405

426

141

699

 

346

265

119

191

Percent

24.2

25.5

8.4

41.8

 

18.8

14.4

6.5

10.4

Age, years

65 ± 8

65 ± 7

65 ± 7

64 ± 9

0.0377

64 ± 8

67 ± 6

66 ± 6

65 ± 7

Male, n (%)

270 (66.7)

282 (66.2)

89 (63.1)

478 (68.4)

0.64

213 (61.6)

175 (66.0)

92 (77.3)

129 (67.5)

BMI, kg/m 2

31 ± 6

32 ± 6

35 ± 6

32 ± 6

<0.0001

33 ± 6

33 ± 6

32 ± 6

34 ± 6

Hemoglobin, g/dL c

13.6 (12.5, 14.8)

13.5 (12.2, 14.5)

13.6 (12.6, 14.5)

13.3 (12.2, 14.4)

0.0833

13.6 (12.3, 14.7)

13.4 (12.5, 14.5)

13.5 (12.5, 14.6)

13.6 (12.5, 14.6)

HbA1c, %

6.7 (6.5, 7.1)

6.7 (6.3, 7.3)

7.5 (6.8, 8.4)

7.5 (6.8, 8.4)

<0.0001

6.9 (6.4, 7.6)

7.1 (6.5, 7.9)

6.8 (6.5, 7.6)

6.9 (6.4, 7.7)

HbA1c, mmol/mol

50 (48, 54)

50 (45, 56)

58 (51, 68)

58 (51, 68)

52 (46, 60)

54 (48, 63)

51 (48, 60)

52 (46, 61)

eGFR, mL/min/1.73 m 2

44 (35, 55)

48 (38, 58)

46 (37, 56)

41 (33, 51)

<0.0001

53 (43, 62)

45 (36, 55)

42 (33, 50)

47 (36,56)

UACR, mg/gCrea

34 (8, 253)

31 (8, 322)

52 (9, 333)

71 (11, 512)

0.0011

38 (7, 369)

50 (9, 329)

45 (9, 371)

29 (6, 202)

CV disease, n(%) b

176 (43.5)

169 (39.7)

72 (51.1)

382 (54.7)

<0.0001

141 (40.7)

120 (45.3)

46 (38.7)

88 (46.1)

Duration of CKD

         

  ≥ 5 years

183 (45.3)

152 (35.7)

56 (39.7)

324 (46.4)

0.0021

121 (34.9)

99 (37.4)

50 (42.0)

68 (35.6)

 3 – < 5 years

65 (16.1)

63 (14.8)

23 (16.3)

115 (16.5)

50 (14.5)

35 (13.2)

20 (16.8)

28 (14.7)

 1 – < 3 years

80 (19.8)

108 (25.3)

25 (17.7)

152 (21.8)

81 (23.4)

69 (26.0)

30 (25.2)

47 (24.6)

  < 1 year

63 (15.6)

84 (19.7)

22 (15.6)

84 (12)

66 (19.1)

50 (18.9)

17 (14.3)

41 (21.4)

  1. Values are reported as numbers and percentages (based on all diabetic patients), mean values ± standard deviation, or medians (25th, 75th percentile), as appropiate
  2. Missings (n = 171) resulted mostly from combinations that were used less frequently
  3. a according to Kruskal-Walis test, analysis of variance, or Chi-Square test, as appropriate
  4. b The composite of cardiovascular disease includes all patients with one or more of the following: cardiac valve replacement, aortic aneurysm, coronary artery disease, cerebrovascular disease, peripheral artery disease
  5. c For conversion into SI units (mmol/L): multiply with 0.62
Back to article page