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Table 2 Baseline variables of renal and vascular endothelial function according to tertiles of SD of HbA1c and SD of FPG

From: Excessive visit-to-visit glycemic variability independently deteriorates the progression of endothelial and renal dysfunction in patients with type 2 diabetes mellitus

  Classified by tertile of SD of HbA1c Classified by tertile of SD of FPG
First tertile group (n = 79) Second tertile group (n = 80) Third tertile group (n = 80) P value First tertile group (n = 79) Second tertile group (n = 80) Third tertile group (n = 80) P value
ACR (mg/mmol)a 1.60 (1.40, 2.25) 1.57 (1.10, 2.72) 1.78 (1.20, 2.52) 0.792 1.60 (1.30, 2.14) 1.58 (1.21, 2.50) 1.80 (1.30, 2.80) 0.306
Creatintine (mg/dl)b 0.73 ± 0.13 0.74 ± 0.13 0.76 ± 0.13 0.429 0.72 ± 0.12 0.74 ± 0.13 0.77 ± 0.14 0.097
Cystatin C (mg/L)b 0.78 ± 0.16 0.83 ± 0.16 0.82 ± 0.16 0.118 0.77 ± 0.16 0.82 ± 0.15 0.83 ± 0.17 0.053
eGFR-Cr (ml · min−1 · 1.73 m−2)b 104.39 ± 26.40 99.89 ± 20.56 96.33 ± 22.21 0.091 102.85 ± 21.48 98.54 ± 22.95 99.19 ± 25.37 0.456
eGFR-Cys C (ml · min−1 · 1.73 m−2)b 102.53 ± 18.30 96.57 ± 19.84 97.28 ± 19.84 0.102 103.26 ± 19.23 97.17 ± 18.16 95.97 ± 19.53* 0.036
FMD (%)b 8.27 ± 3.77 7.56 ± 3.47 8.08 ± 3.83 0.455 8.07 ± 3.57 8.30 ± 3.87 7.54 ± 3.62 0.413
NO (μmol/L)b 61.62 ± 8.90 59.59 ± 9.61 61.47 ± 9.83 0.322 61.09 ± 9.07 62.55 ± 9.60 59.04 ± 9.49 0.061
ET-1 (pg/ml)b 40.56 ± 6.63 40.44 ± 7.47 42.84 ± 6.99*,** 0.055 40.78 ± 6.77 41.46 ± 6.89 41.60 ± 7.66 0.739
  1. Results are means ± SDs or medians (25th, 75th percentiles) for continuous variables and numbers (percentages) for categorical variables
  2. SD standard deviation, HbA1c hemoglobin A1c, FPG fasting plasma glucose, ACR albumin/creatinine ratio, eGFR-Cr estimated glomerular filtration rate base on creatinine, eGFR-Cys C estimated glomerular filtration rate base on cystatin C, FMD flow-mediated dilation, NO nitric oxide, ET-1 endothelin-1
  3. acompared using ANOVA with Bonferroni procedure
  4. bcompared using Kruskal-Wallis test
  5. *P < 0.05, as compared to first tertile group in the same classified groups
  6. **P < 0.05, as compared to second tertile group in the same classified groups