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Table 2 Baseline variables of renal and vascular endothelial function according to tertiles of SD of HbA1c and SD of FPG

From: Excessive visit-to-visit glycemic variability independently deteriorates the progression of endothelial and renal dysfunction in patients with type 2 diabetes mellitus

 

Classified by tertile of SD of HbA1c

Classified by tertile of SD of FPG

First tertile group (n = 79)

Second tertile group (n = 80)

Third tertile group (n = 80)

P value

First tertile group (n = 79)

Second tertile group (n = 80)

Third tertile group (n = 80)

P value

ACR (mg/mmol)a

1.60 (1.40, 2.25)

1.57 (1.10, 2.72)

1.78 (1.20, 2.52)

0.792

1.60 (1.30, 2.14)

1.58 (1.21, 2.50)

1.80 (1.30, 2.80)

0.306

Creatintine (mg/dl)b

0.73 ± 0.13

0.74 ± 0.13

0.76 ± 0.13

0.429

0.72 ± 0.12

0.74 ± 0.13

0.77 ± 0.14

0.097

Cystatin C (mg/L)b

0.78 ± 0.16

0.83 ± 0.16

0.82 ± 0.16

0.118

0.77 ± 0.16

0.82 ± 0.15

0.83 ± 0.17

0.053

eGFR-Cr (ml · min−1 · 1.73 m−2)b

104.39 ± 26.40

99.89 ± 20.56

96.33 ± 22.21

0.091

102.85 ± 21.48

98.54 ± 22.95

99.19 ± 25.37

0.456

eGFR-Cys C (ml · min−1 · 1.73 m−2)b

102.53 ± 18.30

96.57 ± 19.84

97.28 ± 19.84

0.102

103.26 ± 19.23

97.17 ± 18.16

95.97 ± 19.53*

0.036

FMD (%)b

8.27 ± 3.77

7.56 ± 3.47

8.08 ± 3.83

0.455

8.07 ± 3.57

8.30 ± 3.87

7.54 ± 3.62

0.413

NO (μmol/L)b

61.62 ± 8.90

59.59 ± 9.61

61.47 ± 9.83

0.322

61.09 ± 9.07

62.55 ± 9.60

59.04 ± 9.49

0.061

ET-1 (pg/ml)b

40.56 ± 6.63

40.44 ± 7.47

42.84 ± 6.99*,**

0.055

40.78 ± 6.77

41.46 ± 6.89

41.60 ± 7.66

0.739

  1. Results are means ± SDs or medians (25th, 75th percentiles) for continuous variables and numbers (percentages) for categorical variables
  2. SD standard deviation, HbA1c hemoglobin A1c, FPG fasting plasma glucose, ACR albumin/creatinine ratio, eGFR-Cr estimated glomerular filtration rate base on creatinine, eGFR-Cys C estimated glomerular filtration rate base on cystatin C, FMD flow-mediated dilation, NO nitric oxide, ET-1 endothelin-1
  3. acompared using ANOVA with Bonferroni procedure
  4. bcompared using Kruskal-Wallis test
  5. *P < 0.05, as compared to first tertile group in the same classified groups
  6. **P < 0.05, as compared to second tertile group in the same classified groups