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Table 3 HbA1c and FPG profiles and severe hypoglycemic episodes during follow-up period

From: Excessive visit-to-visit glycemic variability independently deteriorates the progression of endothelial and renal dysfunction in patients with type 2 diabetes mellitus

 

Classified by tertile of SD of HbA1c

Classified by tertile of SD of FPG

 

First tertile group (n = 79)

Second tertile group (n = 80)

Third tertile group (n = 80)

P value

First tertile group (n = 79)

Second tertile group (n = 80)

Third tertile group (n = 80)

P value

Mean HbA1c (%)

8.22 ± 1.00

8.33 ± 0.79

8.11 ± 0.56

0.213

8.07 ± 0.65

8.23 ± 0.72

8.35 ± 0.99

0.093

SD of HbA1c (%)

1.41 ± 0.50

2.68 ± 0.36*

3.52 ± 0.47*,**

<0.001

2.05 ± 0.92

2.64 ± 0.81*

2.93 ± 0.99*

<0.001

CV of HbA1c (%)

17.66 ± 4.59

32.48 ± 3.68*

43.89 ± 4.49*,**

<0.001

26.31 ± 9.60

32.21 ± 9.26*

32.75 ± 10.63*

<0.001

Mean FPG (mmol/L)

6.98 ± 0.97

6.92 ± 0.86

6.70 ± 0.55

0.075

6.76 ± 0.64

6.83 ± 0.74

7.02 ± 0.98

0.106

SD of FPG (mmol/L)

3.49 ± 1.27

3.70 ± 0.91

4.26 ± 1.24*,**

<0.001

2.69 ± 0.48

3.68 ± 0.28*

5.09 ± 0.95*, **

<0.001

CV of FPG (%)

50.10 ± 8.62

53.68 ± 7.80*

63.87 ± 8.27*,**

<0.001

39.81 ± 5.34

53.87 ± 6.29*

72.52 ± 8.56*, **

<0.001

Severe hypoglycemic episodes (times)

0.70 ± 0.64

1.09 ± 0.79*

1.94 ± 1.63*,**

<0.001

1.02 ± 1.08

1.32 ± 1.22

1.40 ± 1.33

0.112

  1. Results are means ± SDs
  2. SD standard deviation, CV coefficient of variation, HbA1c hemoglobin A1c, FPG fasting plasma glucose
  3. *P < 0.05, as compared to first tertile group in the same classified groups
  4. **P < 0.05, as compared to second tertile group in the same classified groups