Table 5 Factors possibly related to change percentage of variables of endothelial and renal function throughout follow-up period in total participants
| Â | Change percentage of FMD (%) | Change percentage of NO (%) | Change percentage of ET-1 (%) | Change percentage of ACR (%) | Change percentage of eGFR-Cr (%) | Change percentage of eGFR-Cys C (%) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Weight coefficient (95Â % CI) | P value | Weight coefficient (95Â % CI) | P value | Weight coefficient (95Â % CI) | P value | Weight coefficient (95Â % CI) | P value | Weight coefficient (95Â % CI) | P value | Weight coefficient (95Â % CI) | P value | |
5A. SDs of HbA1c and FPG are included in independent variables in models | ||||||||||||
 SD of HbA1c | −0.158 (−0.211, −0.105) | <0.001 | −0.336 (−0.439, −0.234) | <0.001 | 0.125 (0.059, 0.190) | <0.001 | 0.312 (0.242, 0.382) | <0.001 | −0.334 (−0.394, −0.274) | <0.001 | −0.369 (−0.435, −0.303) | <0.001 |
 SD of FPG | −0.137 (−0.201, −0.072) | <0.001 | −0.200 (−0.323, −0.077) | 0.002 | 0.132 (0.053, 0.211) | 0.001 | 0.090 (0.004, 0.176) | 0.039 | −0.356 (−0.658, −0.054) | 0.002 | −0.453 (−0.832, −0.074) | <0.001 |
 Mean HbA1c | −0.298 (−0.580, −0.016) | <0.001 | -- | -- | -- | -- | 0.789 (0.006, 1.572) | 0.002 | -- | -- | −0.925 (−1.672, −0.178) | 0.022 |
 Mean FPG | -- | -- | −2.306 (−4.294, −0.318) | 0.005 | -- | -- | 1.524 (0.497, 2.551) | 0.009 | -- | -- | −1.188 (−2.369, −0.007) | 0.049 |
 Baseline SBP | −0.141 (−0.270, −0.012) | 0.006 | -- | -- | -- | -- | -- | -- | −0.269 (−0.516, −0.022) | 0.013 | -- | -- |
 Smoking | −0.795 (−1.548, −0.042) | 0.025 | -- | -- | 0.636 (−0.422, 1.694) | 0.047 | 0.971 (0.009, 1.933) | 0.031 | −0.466 (−1.755, −0.823) | 0.038 | −1.335 (−2.248, −0.422) | 0.004 |
 Baseline TCHO | -- | -- | -- | -- | 0.591 (−0.074, 1.256) | 0.041 | -- | -- | -- | -- | −1.925 (−3.572, −0.278) | 0.022 |
 Baseline LDL-c | −0.434 (−0.867, −0.001) | 0.049 | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
5B. CVs of HbA1c and FPG are included in independent variables in models | ||||||||||||
 CV of HbA1c | −0.165 (−0.219, −0.111) | <0.001 | −0.363 (−0.470, −0.256) | <0.001 | 0.114 (0.048, 0.179) | 0.001 | 0.306 (0.273, 0.376) | <0.001 | −0.373 (−0.439, −0.306) | <0.001 | −0.339 (−0.400, −0.279) | <0.001 |
 CV of FPG | −0.141 (−0.206, −0.076) | <0.001 | −0.162 (−0.293, −0.030) | 0.016 | 0.140 (0.061, 0.219) | 0.001 | 0.092 (0.007, 0.176) | 0.034 | −0.118 (−0.225, −0.012) | 0.029 | −0.416 (−0.847, 0.015) | 0.041 |
 Mean HbA1c | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | −0.873 (−1.716, −0.030) | 0.034 |
 Mean FPG | -- | -- | −1.045 (−1.902, −0.178) | 0.015 | -- | -- | 1.530 (0.711, 2.348) | <0.001 | −0.530 (−1.012, −0.048) | 0.034 | −0.966 (−1.257, −0.675) | 0.026 |
 Baseline SBP | −0.065 (−0.127, −0.003) | 0.040 | -- | -- | -- | -- | 0.121 (0.022, 0.219) | 0.017 | -- | -- | -- | -- |
 Baseline TCHO | −0.511 (−1.019, −0.002) | 0.049 | -- | -- | 0.676 (0.045, 1.306) | 0.036 | -- | -- | -- | -- | -- | -- |
 Baseline HDL-c | -- | -- | -- | -- | −1.139 (−2.229, −0.049) | 0.043 | -- | -- | -- | -- | -- | -- |