| |
Change percentage of FMD (%)
|
Change percentage of NO (%)
|
Change percentage of ET-1 (%)
|
Change percentage of ACR (%)
|
Change percentage of eGFR-Cr (%)
|
Change percentage of eGFR-Cys C (%)
|
|---|
|
Weight coefficient (95 % CI)
|
P value
|
Weight coefficient (95 % CI)
|
P value
|
Weight coefficient (95 % CI)
|
P value
|
Weight coefficient (95 % CI)
|
P value
|
Weight coefficient (95 % CI)
|
P value
|
Weight coefficient (95 % CI)
|
P value
|
|---|
|
5A. SDs of HbA1c and FPG are included in independent variables in models
|
|
SD of HbA1c
|
−0.158 (−0.211, −0.105)
|
<0.001
|
−0.336 (−0.439, −0.234)
|
<0.001
|
0.125 (0.059, 0.190)
|
<0.001
|
0.312 (0.242, 0.382)
|
<0.001
|
−0.334 (−0.394, −0.274)
|
<0.001
|
−0.369 (−0.435, −0.303)
|
<0.001
|
|
SD of FPG
|
−0.137 (−0.201, −0.072)
|
<0.001
|
−0.200 (−0.323, −0.077)
|
0.002
|
0.132 (0.053, 0.211)
|
0.001
|
0.090 (0.004, 0.176)
|
0.039
|
−0.356 (−0.658, −0.054)
|
0.002
|
−0.453 (−0.832, −0.074)
|
<0.001
|
|
Mean HbA1c
|
−0.298 (−0.580, −0.016)
|
<0.001
|
--
|
--
|
--
|
--
|
0.789 (0.006, 1.572)
|
0.002
|
--
|
--
|
−0.925 (−1.672, −0.178)
|
0.022
|
|
Mean FPG
|
--
|
--
|
−2.306 (−4.294, −0.318)
|
0.005
|
--
|
--
|
1.524 (0.497, 2.551)
|
0.009
|
--
|
--
|
−1.188 (−2.369, −0.007)
|
0.049
|
|
Baseline SBP
|
−0.141 (−0.270, −0.012)
|
0.006
|
--
|
--
|
--
|
--
|
--
|
--
|
−0.269 (−0.516, −0.022)
|
0.013
|
--
|
--
|
|
Smoking
|
−0.795 (−1.548, −0.042)
|
0.025
|
--
|
--
|
0.636 (−0.422, 1.694)
|
0.047
|
0.971 (0.009, 1.933)
|
0.031
|
−0.466 (−1.755, −0.823)
|
0.038
|
−1.335 (−2.248, −0.422)
|
0.004
|
|
Baseline TCHO
|
--
|
--
|
--
|
--
|
0.591 (−0.074, 1.256)
|
0.041
|
--
|
--
|
--
|
--
|
−1.925 (−3.572, −0.278)
|
0.022
|
|
Baseline LDL-c
|
−0.434 (−0.867, −0.001)
|
0.049
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
5B. CVs of HbA1c and FPG are included in independent variables in models
|
|
CV of HbA1c
|
−0.165 (−0.219, −0.111)
|
<0.001
|
−0.363 (−0.470, −0.256)
|
<0.001
|
0.114 (0.048, 0.179)
|
0.001
|
0.306 (0.273, 0.376)
|
<0.001
|
−0.373 (−0.439, −0.306)
|
<0.001
|
−0.339 (−0.400, −0.279)
|
<0.001
|
|
CV of FPG
|
−0.141 (−0.206, −0.076)
|
<0.001
|
−0.162 (−0.293, −0.030)
|
0.016
|
0.140 (0.061, 0.219)
|
0.001
|
0.092 (0.007, 0.176)
|
0.034
|
−0.118 (−0.225, −0.012)
|
0.029
|
−0.416 (−0.847, 0.015)
|
0.041
|
|
Mean HbA1c
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
−0.873 (−1.716, −0.030)
|
0.034
|
|
Mean FPG
|
--
|
--
|
−1.045 (−1.902, −0.178)
|
0.015
|
--
|
--
|
1.530 (0.711, 2.348)
|
<0.001
|
−0.530 (−1.012, −0.048)
|
0.034
|
−0.966 (−1.257, −0.675)
|
0.026
|
|
Baseline SBP
|
−0.065 (−0.127, −0.003)
|
0.040
|
--
|
--
|
--
|
--
|
0.121 (0.022, 0.219)
|
0.017
|
--
|
--
|
--
|
--
|
|
Baseline TCHO
|
−0.511 (−1.019, −0.002)
|
0.049
|
--
|
--
|
0.676 (0.045, 1.306)
|
0.036
|
--
|
--
|
--
|
--
|
--
|
--
|
|
Baseline HDL-c
|
--
|
--
|
--
|
--
|
−1.139 (−2.229, −0.049)
|
0.043
|
--
|
--
|
--
|
--
|
--
|
--
|
- Independent variables include age, sex, current smoking, current drinking, duration of diabetes, body mass index, baseline blood press, baseline blood lipids, baseline fasting plasma glucose, baseline HbA1c, mean fasting plasma glucose and HbA1c during follow-up, standard deviation of fasting plasma glucose and HbA1c during follow-up, coefficient of variation of fasting plasma glucose and HbA1c during follow-up, and episodes of severe hypoglycemia over follow-up period
- ACR albumin/creatinine ratio, eGFR-Cr estimated glomerular filtration rate based on creatinine, eGFR-Cys C estimated glomerular filtration rate based on cystatin C, TCHO total cholesterol, DBP diastolic blood pressure, FPG fasting plasma glucose, HbA1c hemoglobin A1c, CV coefficient of variation, SD standard deviation
