Fig. 4

Hematological and biochemical analysis of Ksp-Keap1 ^-/- mice. a and b Complete blood count analysis showed comparable leucocyte and platelet counts in Ksp-Keap1 ^-/- and Keap1 ^f/f mice. c Ksp-Keap1 ^-/- mice had significantly higher red blood cells (9.6 ± 0.3 vs 9 ± 0.1 M/μL, p = 0.04), hemoglobin (13.9 ± 0.6 vs 12.5 ± 0.2 g/dL, p = 0.01), hematocrit (47.3 ± 2.0 % vs 42.3 ± 0.6, p = 0.02), mean cell volume (49 ± 1.0 vs 46.7 ± 0.5 fL, p = 0.02) and mean cell Hb concentration (14.4 ± 0.2 vs 13.8 ± 0.1 g/dL, p = 0.003) in comparison to age matched Keap1 ^f/f mice. d Chloride level in serum was significantly higher (120 ± 1 vs 115 ± 3 mmol/L, p = 0.05) in Ksp-Keap1 ^-/- mice as compared to Keap1 ^f/f control mice. e Urinary calcium (1.3 ± 1.2 vs 3.9 ± 0.3 mg/dL, p = 0.02) and total protein (0.1vs 0.3 g/dL, p = 0.007) were significantly lower in Ksp-Keap1 ^-/- mice as compared to Keap1 ^f/f mice. Data are presented as mean ± standard deviation (SD)