Stroke | No Stroke | Peripheral Arterial Disease | No Peripheral Arterial Disease | ||||||
---|---|---|---|---|---|---|---|---|---|
Smoking Status | Smoking Status | Smoking Status | Smoking Status | ||||||
Yes | No | Yes | No | Yes | No | Yes | No | ||
(n = 8,384) | (n = 107, 806) | 60,339 | 1,043,406 | (n = 14, 960) | (n = 163, 846) | 53,763 | 987,379 | ||
Demographics | |||||||||
Age (years) | 61.9 (11.7) | 68.4 (12)* | 56 (13.8) | 62.6 (15.5)* | 63.1 (11.3) | 68.1 (11.9)* | 55 (13.8) | 62.3 (15.7)* | |
Gender (%) | |||||||||
Male | 63.3 | 52.5* | 64.3 | 53.9* | 65.4 | 57.9* | 63.9 | 53.1* | |
Race (%) | |||||||||
White | 69.1 | 66.2* | 64.2 | 65.3* | 79 | 76.2* | 60.9 | 63.6* | |
Black | 28.6 | 29.5 | 33.1 | 29.6* | 18.8 | 20.3* | 36.4 | 31.1* | |
Asian | 1.1 | 3.3* | 1.4 | 4* | 0.8 | 2.1* | 1.6 | 4.2* | |
Native American | 1.3 | 0.9 | 1.2 | 1.1 | 1.4 | 1.4 | 1.2 | 1.1 | |
Hispanic (%) | |||||||||
Hispanic | 2.3 | 5.8* | 3.1 | 8.3* | 2.8 | 7.2* | 3 | 8.2* | |
Comorbid Conditions (%) | |||||||||
Diabetes (cause of ESKD)a | 44 | 52.1* | 35.6 | 45.2* | 48.5 | 59.4* | 33.4 | 43.5* | |
Diabetes (comorbid condition) | 54 | 61.8* | 43.3 | 52.4* | 57.9 | 68* | 40.9 | 50.9* | |
Hypertension | 91.1 | 87.2* | 84.5 | 78.2* | 89.7 | 85.8* | 84.1 | 77.9* | |
Heart Failure | 45 | 46.8 | 31.9 | 31.7 | 52 | 56.9* | 28.3 | 29.1* | |
Coronary Disease | 47.7 | 44.3* | 25.3 | 23.7* | 55.6 | 55.4 | 20.4 | 20.7 | |
Stroke | 22.4 | 19.5* | 9.4 | 7.7* | |||||
Peripheral Arterial Disease | 40 | 29.6* | 19.2 | 12.6* | |||||
Chronic lung disease | 35.7 | 11.9* | 23.5 | 6.7* | 43.6 | 14.2* | 19.8 | 6* | |
Malignancy | 8 | 7.3 | 6.5 | 6.2 | 7.4 | 6.1* | 6.5 | 6.4 | |
Body Mass Index (kg/m2) | 25.5 (6.6) | 26.8 (6.8)* | 26.2 (7) | 27.7 (7.4)* | 25.6 (6.7) | 27.4 (7.3)* | 26.2 (7) | 27.6 (7.4)* | |
Lifestyle factors (%) | |||||||||
Alcohol Dependence | 8.2 | 1.0* | 9.5 | 1.1* | 6.1 | 0.8* | 10.3 | 1.1* | |
Drug dependence | 4.2 | 0.6* | 7.4 | 0.8* | 2.7 | 0.4* | 8.2 | 0.9* | |
Functional Status (%) | |||||||||
Inability to walk independently | 11.5 | 13.6* | 4.6 | 4.3* | 11.3 | 11.9 | 3.8 | 4 | |
Inability to transfer independently | 4.3 | 6.5* | 1.4 | 1.7* | 3.5 | 4.8* | 1.2 | 1.7* | |
Employment Status (%) | |||||||||
Full time employment | 3 | 2.2* | 9 | 8.8 | 4 | 3.1* | 9.4 | 9* | |
Part time employment | 0.8 | 0.7 | 2.2 | 1.9* | 1.4 | 1* | 2.2 | 1.9* | |
Unemployed | 19.6 | 14.1* | 28.1 | 19.9* | 16.1 | 13.3* | 30.1 | 20.3* | |
Homemaker | 3.6 | 5* | 3.1 | 4.9* | 3.6 | 4.9* | 3 | 4.9* | |
Retired from age | 35.8 | 51.2* | 24.6 | 39.5* | 39.3 | 51.3* | 22.2 | 38.8* | |
Retired from disability | 33 | 23.3* | 26.6 | 18.5* | 31.2 | 22.3* | 26.4 | 18.4* | |
Medical leave of absence | 1.9 | 1.2* | 4 | 3.1* | 2 | 1.3* | 4.3 | 3.2* | |
Student | 0.05 | 0.05 | 0.1 | 0.3* | 0.03 | 0.04 | 0.2 | 0.3* | |
Other | 2.3 | 2.4 | 2.3 | 3.1* | 2.4 | 2.7 | 2.3 | 3.1* | |
Laboratory Variables | |||||||||
Serum Creatinine (μmol/L) | 616 (259) | 580 (244)* | 702 (340) | 658 (317)* | 594 (248) | 564 (228)* | 719 (347) | 665 (321)* | |
eGFRb (ml/min/1.73 m2) | 8.7 (3.7) | 8.6 (3.6) | 8.1 (3.8) | 8.1 (3.7)* | 8.9 (3.8) | 8.9 (3.7) | 8 (3.8) | 8 (3.6) | |
Albumin (g/L) | 30.7 (6.7) | 30.9 (6.6) | 3.1 (0.7) | 3.1 (0.7)* | 30.6 (6.8) | 30.7 (6.6) | 3.1 (0.7) | 3.2 (0.7)* | |
Pre-ESRD Care (%) | |||||||||
Erythropoietin use pre-dialysis | 25.6 | 30.1* | 24.2 | 29.2* | 28.2 | 32.7* | 23.3 | 28.7* | |
Dialysis Modality at day 90 (%) | |||||||||
Peritoneal Dialysis | 5.9 | 4.5* | 7.7 | 7.2* | 6.2 | 4.9* | 7.8 | 7.3* | |
Hemodialysis | 80.4 | 79.8 | 81 | 80.4* | 79.5 | 79.2 | 81.3 | 80.6* |