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Table 4 Hazards Ratios (HR) for Kidney Transplantation for each Atherosclerotic Condition by Smoking Status among new dialysis Patientsa

From: Differential impact of smoking on mortality and kidney transplantation among adult Men and Women undergoing dialysis

 

With Coronary Disease

Without Coronary Disease

Group

Smokers

Non-smokers

Smokers

Non-smokers

 

HR (95 % CI)

HR (95 % CI)

HR (95 % CI)

HR (95 % CI)

    

Referent

 Unadjusted

0.31 (0.28–0.34)

0.35 (0.34–0.36)

0.78 (0.76–0.81)

1.00

 Demographic-adjustedb

0.36 (0.33–0.40)

0.59 (0.57–0.61)

0.60 (0.57–0.62)

1.00

 Adjusted for all covariatesc

0.61 (0.53–0.69)

0.76 (0.73–0.79)

0.74 (0.70–0.78)

1.00

 

With Stroke

Without Stroke

 

Smokers

Non-smokers

Smokers

Non-smokers

 

HR (95 % CI)

HR (95 % CI)

HR (95 % CI)

HR (95 % CI)

    

Referent

 Unadjusted

0.31 (0.26–0.36)

0.31 (0.30–0.33)

0.79 (0.76–0.82)

1.00

 Demographic-adjustedb

0.34 (0.29–0.40)

0.50 (0.48–0.52)

0.59 (0.57–0.61)

1.00

 Adjusted for all covariatesc

0.50 (0.40–0.63)

0.64 (0.59–0.68)

0.75 (0.71–0.79)

1.00

 

With Peripheral Arterial Disease

Without Peripheral Arterial Disease

 

Smokers

Non-smokers

Smokers

Non-smokers

 

HR (95 % CI)

HR (95 % CI)

HR (95 % CI)

HR (95 % CI)

    

Referent

 Unadjusted

0.32 (0.29–0.36)

0.32 (0.31–0.33)

0.81 (0.78–0.84)

1.00

 Demographic-adjustedb

0.35 (0.31–0.39)

0.46 (0.44–0.48)

0.59 (0.57–0.62)

1.00

 Adjusted for all covariatesc

0.57 (0.48–0.67)

0.66 (0.62–0.70)

0.74 (0.70–0.78)

1.00

  1. aHazard Ratios for first kidney transplant (HR) and 95 % confidence intervals
  2. bDemographic variables of age, gender and race
  3. cFinal multivariable model adjusted for demographic characteristics (age, sex and race), clinical conditions (diabetes, hypertension, coronary disease, peripheral vascular disease, cerebrovascular disease, heart failure, pulmonary disease, cancer, AIDS, body mass index), lifestyle and functional factors (difficulty in walking and transfers, alcohol use), socioeconomic factors (employment status), erythropoietin use pre-dialysis, and laboratory factors (serum albumin, eGFR at dialysis initiation). Note the atherosclerotic condition was not included in the adjusted analysis, if it was the primary stratifying variable