Table 1 Characteristics and outcomes of patients treated with plasma exchange after primary post-renal transplant focal segmental glomerulosclerosis (1950–2012)
Median or n (% of available data) | Data not reported n (% of 423) | |
|---|---|---|
Characteristics at time of recurrence | ||
Age at time of treatment (years), median (IQR) | 17 (12,33) | 188 (44 %) |
< 18 years, n (%) | 119/235 (50.6 %) | |
Gender, n (%) | 211 (50 %) | |
Male | 126/212 (59.4 %) | |
Female | 86/212 (40.6 %) | |
Time to recurrence (days), median (IQR) | 4 (1,18) | 131 (31 %) |
Proteinuria (g/day), median (IQR) | 7 (5,12) | 275 (65 %) |
Biopsy conducted, n (%) | 211/266 (79.3 %) | 157 (37 %) |
Kidney transplant type, n (%) | 248 (59 %) | |
Living donor | 62/175 (35.4 %) | |
Deceased donor | 113/175 (64.6 %) | |
Treatment characteristics | ||
Time from recurrence to start of plasma exchange (days), median (IQR) | 1 (0,3) | 193 (46 %) |
Delayed treatment start, n (%) | 193 (46 %) | |
More than two weeks | 28/230 (12.2 %) | |
More than one month | 22/230 (9.6 %) | |
Total number of plasma exchange sessions, median (IQR) | 12 (10,20) | 191 (45 %) |
Total weeks of plasma exchange treatment, median (IQR) | 12 (4,28) | 309 (73 %) |
Received rituximab | 41/404 (4.7 %) | 19 (4 %) |
Received steroids | 341/344 (99.1 %) | 79 (19 %) |
Post-treatment outcomes | ||
Remission, n (%) | 317/423 (74.0 %) | 0 |
Complete remission (proteinuria <0.5 g/day) | 198/423 (46.8 %) | |
Partial remission (proteinuria: 0.5–3.5 g/day)a | 119/423 (28.1 %) | |
eGFR at follow up (ml/min/1.73 m2), median (IQR) | 44 (25,74) | 288 (68 %) |
Proteinuria at follow-up (g/day), median (IQR) | 0.2 (0,2) | 259 (61 %) |
End-stage renal disease, n (%) | 83/381 (21.8 %) | 42 (10 %) |
Time to ESRD after transplant (years), median (IQR) | 0.9 (0.3,2.0) | 383 (91 %) |