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Table 2 Effect of sodium bicarbonate therapy

From: Effect of oral sodium bicarbonate on fibroblast growth factor-23 in patients with chronic kidney disease: a pilot study

  Initial 2-week placebo p-value
Serum Bicarbonate (mEq/L) 23.0 ± 2.3 22.2 ± 2.8 0.17
FGF23 (RU/mL) 157.4 (90.2–289.4) 161.7 (104.5–245.5) 0.91
  Before sodium bicarbonatea After sodium bicarbonate p-value
Systolic blood pressure (mmHg) 131 ± 11 130 ± 14 0.71
Diastolic blood pressure (mmHg) 69 ± 8 70 ± 10 0.66
Serum Bicarbonate (mEq/L) 22.6 ± 2.3 25.5 ± 2.2 < 0.001
eGFR (ml/min per 1.73 m2) 40.6 ± 15.6 40.0 ± 15.1 0.65
FGF23 (RU/mL) 150.9 (107.7–267.43) 191.4 (132.6–316.9) 0.048
25-OH vitamin D (ng/mL) 36 ± 13 37 ± 14 0.60
1, 25-OH vitamin D (pg/mL)c 42 (21–58) 42 (18–57) 0.79
Serum calcium (mg/dL) 9.9 ± 0.5 9.9 ± 0.5 0.39
Serum phosphate (mg/dL) 4.0 ± 0.8 3.9 ± 0.8 0.31
Urine calcium (mg/mg Cr)b 0.03 (0.02–0.04) 0.01 (0.01–0.05) 0.09
Urine phosphate (mg/mg Cr)b 0.47 (0.28–0.61) 0.42 (0.32–0.55) 0.84
Urine sodium (mg/mg Cr)b 2.4 ± 0.7 2.8 ± 1.0 0.07
Fractional excretion of phosphate (%) 18 (14–24) 21 (15–26) 0.22
Fractional excretion of sodium (%) 1.4 (1.1–2.4) 1.6 (1.1–2.2) 0.44
  1. Serum bicarbonate, 25-OH vitamin D, serum calcium, phosphate and urine sodium were expressed as mean ± standard deviation. FGF23, 1,25-OH vitamin D, urine calcium and phosphate, fractional excretion of phosphate and sodium were expressed in median (interquartile range)
  2. Abbreviations: eGFR estimated glomerular filtration rate, 25-OH vitamin D 25-hydroxyvitamin D, 1,25-OH vitamin D 1,25-dihydroxyvitamin D, FGF23 fibroblast growth factor-23
  3. aValues of variables for “before sodium bicarbonate” were the mean of values between the initial visit and after 2-week placebo
  4. burine calcium, phosphate and sodium were normalized by dividing urine creatinine. The mean urinary sodium increased from 2.4 ± 0.7 to 2.6 ± 0.9 mg/mg Cr after excluding 2 participants who had their diuretics dose increased prior to the last visit (p = 0.20)
  5. cOnly 11 participants had 1,25-OHvitamin D level available at before and after 6-week sodium bicarbonate therapy