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Table 2 Baseline data: “controls”: 47 pregnant patients on unrestricted diet in pregnancy (22 singleton deliveries in Cagliari, 20 in Torino)

From: Vegan-vegetarian low-protein supplemented diets in pregnant CKD patients: fifteen years of experience

Case Age (yrs) Pre-conceptional; Referral-week Kidney disease sCr mg/dL (EPI-GFR mL/min) CKD stage PtU (g/24 h) Pt/Alb (g/dL) HT Therapy at referral BMI
1 33 11w IgA GN 0.9 (84.3) 2 1.1 6.0/2.9 No Pred 20.2
2 34 pre; 7w SLE 0.7 (113.4) 1 1.3 5.8/3.5 No Steroids, AZA 19.6
3 34 pre; 6w SLE 0.7 (113.4) 1 1.3 6.3/2.9 Yes a-MD, Pred., CyA 20.8
4 38 pre; 22w Unknown 0.8 (93.8) 1 1.7 Na Yes ASA, Nifedipine, a-MD 26
5 29 pre; 5w IgA GN 0.9 (86.7) 2 2.1 6.3/3.5 Yes a-MD 22.1
6 26 pre; 8w Diab neph 0.4 (144.2) 1 2.6 5.6/3.3 No ASA, Insulin 23.4
7 35 pre; 7w SLE, LLAC 0.5 (129.3) 1 3.9 5.2 /2.9 No Pred 20.2
8 19 pre; 13w SLE 0.6 (135.6) 1 4 5.9/3 No none 18.8
9 36 pre; 13w FSGS 0.9 (82.5) 2 4.2 5.7/3.1 Yes ASA, a-MD 20.3
10 41 pre; 6w SLE 1 (71.9) 2 5.4 5.5/3.6 Yes a-MD 18.3
11 35 pre; 20w Diab neph 1.2 (58.7) 3 0.1 Na Yes a-MD, Insulin 25.6
12 39 pre; 7w SLE 1.4 (47.4) 3 0.3 6.5/3.7 Yes Pred., AZA 23
13 32 pre; 9w SLE 1.4 (49.8) 3 0.8 6.7/4.5 Yes Pred 21.6
14 35 pre; 8w IgA GN 1.4 (50) 3 1.7 6.8/3.3 No none 24.8
15 38 pre; 7w Unknown 1.6 (40.6) 3 1.4 6.2/4.3 No none 23.9
16 31 6w IgA GN 1.6 (42.6) 3 ++ 7/3.3 No none 32.5
17 36 pre; 6w GN 1.8 (35.7) 3 0.4 7.3/ 4 No none 22.5
18 23 pre; 13w Unknown 1.9 (36.6) 3 2.8 6.1/ 3 No none 30.1
19 30 na IgA GN 1.4 (50) 3 6.2 na Yes a-MD 21.6
20 34 pre; 12w SLE, LLAC 2.2 (28.4) 4 1.2 5.7/3.2 Yes a-MD, ASA, EPO 21.4
21 28 7w Unknown 1.6 (43.9) 3 1.6 7.4/ 4.3 No none 23.7
22 33 pre; 12w GN 0.5 (127.6) 1 1.1 7/4 No none 21.8
Summary data
Cagliari
34 (19–41) 8 (5–22)   sCr
1.1 (0.4–2.2)
GFR-EPI
65.3 (28.4–144.2)
  1.6 (0.1–6.2) Pt
6.2 (5.2–7.4)
Alb
3.3 (2.9–4.5)
10
45.5 %
  21.95 (18.3–32.5)
1 39 Pre; 8 w Interstitial 1.6 (40) 3 1.3 7.3 /3.7 Yes Felodipine, Doxazosin, Levotiroxina, ASA 26.7
2 27 14 w Reflux 1.5 (47) 3 0.3 6.5/3.4 No None 18.0
3 34 20 w Chronic PN 1.5 (45) 3 2.0 Na No None 23.3
4 23 13 w IgA GN 1.3 (56) 3 0.5 6.4/3.1 Yes a-MD, ASA 22.7
5 32 Pre; 5 w IgA GN 1.2 (58) 3 0.3 6.1/3.4 No Steroids, Allopurinole 19.1
6 35 Pre; 8 w IgA GN 1.3 (54) 3 0.5 6.6/2.7 Yes a-MP, Niphedipine 24.4
7 22 27 w Reflux 2.9 (22) 4 0.5 7.3/3.4 No Niphedipine 22.2
8 39 Pre; 14 w Chronic PN 1.4 (47) 3 0.2 8.1/4.0 Yes B-bloc, ASA 18.4
9 31 20 w Reflux 1.3 (54) 3 0.6 7.2/3.7 Yes B-bloc, Doxazosine, Niphedipine, Isosorbide 19.5
10 25 33 w Reflux 1.3 (57) 3 0.8 6.0/3.1 Yes a-MP 19.3
11 35 7; w Interstitial 1.3 (52) 3 0.6 6.0/3.2 Yes None 25.6
12 33 Pre; 12w Chronic PN 1.2 (60) 3 0.1 6.4/3.2 No Clonidine, a-MP, ASA 19.7
13 30 6 w Kidney graft 1.2 (59) 3 0.2 7.6/3.2 No TAC, Pred, Pantoprazole, Allopurinolo 20.3
14 32 29 w HIV neph. 1.43 (56) 3 0.4 7.0/3.1 No Antiretroviral therapy Omeprazole 20.0
15 36 6 w Kidney graft 1.1 (56) 3 0.1 6.9/4.7 No Pred, CyA, Omeprazole, ASA 24.7
16 38 Pre; 8 w single kidney 0.8 (56) 3 0.1 6.8/4.4 No Calcium carbonate 15.6
17 27 5 w SLE 0.6 (193.6) 1 1.45 7.09/4.37 No ASA, Steroids 30.4
18 37 20 w FSGS 0.7 (81.6) 2 2.33 6.56/3.62 No none 23.6
19 26 12 w IR e proteinuria 1.1 (101.2) 1 2 6.45/3.49 No ASA 32.4
20 36 16 w PNC 0.6 (122) 1 1.03 7.55/4.10 No Thyroxine 20.2
21 (miscarriage) 38 7 w Chronic PN, single kidney 1.9 (31) 3 0.1 7.3/5.0 No None 24.9)
22 (miscarriage) 37 Pre; 8 w Single kidney 0.8 (58) 3 0.1 7.6/4.7 No None 15.6
23 (miscarriage) 36 5 w Kidney graft 1.3 (53) 3 0.4 Na No CyA, AZA 25.5
24 (miscarriage) 37 Pre; 5 w single kidney 0.9 (55) 3 0.1 na No Calcium carbonate, 16.2
25 (miscarriage) 30 9 w Diab. Neph 1.4 (50) 3 0.2 6.9/4.1 No Insuline 22.7
Summary data Torino 34
(22–39)
9 (5–33) _ sCr
1.3 (0.6–2.9)
GFR-EPI
56.0 (22.0–193.6)
3 (1–4) 0.4
(0.1–2.33)
Pt
6.9 (6.0–8.1)
Alb
3.55 (2.7–5.0)
7
28.0 %
_ 22.2 (15.6–32.4)
Summary data all controls:
42 singleton
33.5 (19–41) 9 (5–33) _ sCr
1.25 (0.4–2.9)
GFR-EPI
56.0 (22.0–193.6)
3 (1–4) 1.1
(0.1–6.2)
Pt
6.5 (5.2–8.1)
Alb
3.4 (2.7–4.7)
17
40.5 %
_ 21.95 (15.6–32.5)
P cases vs controls (singletons) 0.443 0.154 _ sCr
0.716
GFR-EPI
0.680
0.139
Chi 2
0.585 Pt
0.952
Alb
0.073
0.479
(Chi2)
_ 0.237
  1. Data at referral: data observed at the first follow-up in our unit
  2. HT hypertension, SLE systemic lupus erythematosus, IgA GN IgA nephropathy, FSGS focal segmental glomerlosclerosis, Diab Neph diabetic nephropathy, BMI body mass index, PtU 24 hour proteinuria, sCr serum creatinine, GFR glomerular filtration rate, SLE systemic lupus (erithematosus)elim erythematosus. CyA cyclosporine A, ASA acetyl salicylic acid, Pred. prednisone, TAC tacrolimus, EPO erythropoietin, B-Bloc beta blocker, a-MD alpha methyldopa