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Fig. 1 | BMC Nephrology

Fig. 1

From: Role of low protein diet in management of different stages of chronic kidney disease - practical aspects

Fig. 1

Hypothesis proposed by Brenner et al. [13]. Unrestricted protein intake in the face of decreased number of functioning nephrons leads to increase in glomerular capillary flow and glomerular capillary pressure. These hemodynamic changes lead to glomerulosclerosis. This results in further reduction in functioning nephrons and setting up of a vicious cycle which culminates in end stage renal disease

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