| |
T0
|
T2
|
T4
|
T8
|
T12
|
|---|
|
Ci (ng/mL)
|
879 (733, 1466)
|
850 (685, 1525)
|
859 (688, 1496)
|
847 (689, 1417)
|
844 (694, 1405)
|
|
Co (ng/mL)
|
867 (697, 1451)
|
845 (703, 1332)
|
890 (661, 1416)
|
834 (689, 1326)
|
819 (646, 1415)
|
|
Cuf (ng/mL)
|
32.2 (26.7, 40.8)
|
30.3 (23.6, 34.9)
|
27.7 (24.1, 31.9)
|
26.1 (21.2, 30.1)
|
24.0 (20.1, 28.0)
|
|
Mi (μg/min)
|
107 (94, 183)
|
104 (97, 194)
|
105 (89, 197)
|
105 (91, 182)
|
110 (88, 180)
|
|
Mo (μg/min)
|
104 (92, 181)
|
107 (88, 170)
|
109 (85, 182)
|
107 (89, 170)
|
109 (85, 172)
|
|
Muf (ng/min)
|
2189 (1330, 2748)
|
1807 (1181, 3363)
|
1888 (1309, 2312)
|
2048 (1129, 3693)
|
1397 (1018, 3471)
|
|
Mtr (ng/min)
|
1430 (239, 4914)
|
1502 (−2500, 4801)
|
3240 (593, 5544)
|
3024 (−82, 5360)
|
4620 (2540, 6687)
|
|
Mad (ng/min)
|
−313(−2576, 3470)
|
−1369 (−5611, −1682)
|
1651 (−1494, 3308)
|
354 (−2195, 3201)
|
2216 (507, 5104)
|
|
SC
|
0.21 (0.17, 0.26)
|
0.19 (0.16, 0.22)
|
0.17 (0.15, 0.21)
|
0.16 (0.13, 0.20)
|
0.16 (0.12, 0.18)
|
|
Clearance
|
2.05 (0.39, 3.57)
|
1.45 (−3.15, 4.28)
|
3.74 (0.73, 6.09)
|
3.56 (−0.45, 5.80)
|
4.57 (1.85, 8.94)
|
- Data are presented as median (25th, 75th percentiles). CVVH continuous venovenous hemofiltration, NGAL neutrophil gelatinase-associated lipocalin, Ci concentration in inlet plasma before addition of replacement fluid, Co concentration in outlet plasma, Cuf concentration in the ultrafiltrate, Mad mass adsorption rate, Muf mass ultrafiltration rate, Mi mass inlet rate, Mo mass outlet rate, Mtr mass removal rate, SC sieving coefficient
