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Table 1 Characteristics of warfarin studies in patients with end stage renal disease and atrial fibrillation

From: Warfarin use and stroke, bleeding and mortality risk in patients with end stage renal disease and atrial fibrillation: a systematic review and meta-analysis

Author Year Setting Study duration (years) Study population Study groups Number of patients with ESRD and AF % Female Mean age (SD) (years) % With stroke/TIA/TE history % With bleeding history
Chan 2009 [30] US, Fresenius clinics 1.6 Patients with incident HD, pre-existing AF T (total) 1671 NR NR NR NR
W (warfarin) 746 NR NR NR NR
C (no warfarin) 925 NR NR NR NR
Lai 2009 [32] US, single center 2.6 All patients with CKD (HD and GFR < 15 mL/min/1.73 m2) and pre-existing non-valvular AF, includes prevalent warfarin users T (total) 245 NR NR NR NR
W (warfarin) 129 NR NR NR NR
C (no warfarin) 96 NR NR NR NR
Wizemann 2010 [33] International consortium 8 Patients with HD who had pre-existing or newly developed AF, includes prevalent warfarin users T (total) 3245 NR NR NR NR
W (warfarin) 509 NR NR NR NR
C (no warfarin) 2736 NR NR NR NR
Winkelmayer 2011 [22] US, New Jersey, Pennsylvania Medicare claims 22 All patients with incident dialysis ≥ 66 years who had first hospitalization with a primary or secondary discharge diagnosis of AF T (total) 2313 NR NR NR NR
W (warfarin) 249 57.4 68.6 (12.1) NR 6.8
C (no warfarin) 2064 57.5 70.1 (11.9) NR 16.2
Olesen 2012 [23] Denmark, national registry 12 All patients discharged from the hospital with a diagnosis of non-valvular AF, receiving RRT T (total) 901 33.6 66.8 (11.7) 14.8 15.2
W (warfarin only) 178 NR NR NR NR
C (no warfarin) 723 NR NR NR NR
Khalid 2013 [34] US, multi-center 6 Patients who were started on warfarin in the last year and re-started warfarin for atrial fibrillation after a gastrointestinal bleed T (total) 96 31.3 77.2 (10.6) 52.1 21.2
W (restarted warfarin) 34 NR NR NR NR
C (did not restart warfarin) 62 NR NR NR NR
Wakasugi 2014 [29] Japan, multi-center 3 Patients aged ≥ 20 years with ESRD requiring HD and pre-existing chronic sustained AF, includes prevalent warfarin users T (total) 60 NR NR NR NR
W (warfarin) 28 43 67.8 (9.4) 14 NR
C (no warfarin) 32 28 68.4 (8.5) 36 NR
Bonde 2014 [24] Denmark, national registry 15 Incident non-valvular AF discharge, receiving RRT, stratified by CHA2DS2-VASc score T (total) 1142 35.03 66.77 (12.03) 16.37 17.51
W (warfarin) 260 NR NR NR NR
C (no warfarin) 882 NR NR NR NR
Carrero 2014 [25] Sweden, national registry 7 Survivors of acute myocardial infarction, history of AF or AF diagnosis in hospital, eGFR ≤ 15 ml/min/173 m2 T (total) 478 NR NR NR NR
W (warfarin) 66 37.9a 78a (NR) 28.8a 12.1a
C (no warfarin) 412 38.8a 77a (NR) 26.5a 22.8a
Chen 2014 [26] Taiwan, national registry 4.12 Adult (≥18 years) patients with ESRD, receiving RRT, pre-existing non-valvular AF T (total) 3277 NR NR NR NR
W (warfarin) 294 58.5 NR NR NR
C (no warfarin) 2983 53.7 NR NR NR
Friberg 2014 [13] Sweden, national registry 2.1 Any inpatient diagnosis of non-valvular AF, receiving RRT, includes prevalent warfarin users T (total) 13435 35.7 78.4 (10.3) 24.6 30.5
W (warfarin) 3766 NR NR NR NR
C (no warfarin) 9669 NR NR NR NR
Shah 2014 [27] Canada, Quebec & Ontario regional claims 9 Patients aged ≥ 65 years admitted to a hospital with a primary or secondary diagnosis of AF who underwent > = 3 dialysis procedure within the 12 months preceding AF T (total) 1626 NR NR NR NR
W (warfarin) 756 39 75.3 (8.1) 6 9
C (no warfarin) 870 39 75.1 (8.5) 5 16
Genovesi 2015 [31] Italy, multi-center 2 Patients with HD, pre-existing paroxysmal, persistent or permanent AF, includes prevalent warfarin users T (total) 290 40.0 NR 14.8 19.7
W (warfarin) 134 35.8 NR 15.7 11.9
C (no warfarin) 156 43.6 NR 14.1 26.3
Chan KE 2015 [20] US, Fresenius clinics 4 Patients with chronic HD, pre-existing AF T (total) 14607 NR NR NR NR
W (warfarin) 8064 38.8 70.6 (11) 12.7 3.3
A (aspirin) 6018 42.7 71.7 (11) 14.3 0.7
D (dabigatran) 281 40.8 68.4 (12) 12.5 4.1
R (rivaroxaban) 244 39.5 66.9 (12) 16.0 4.2
Chan PH 2015 [21] China, single center 14.5 Patients with PD who had a diagnosis of AF treated in two hospitals, exclude HD or CKD stage 5 not on RRT, includes prevalent warfarin users T (total) 271 NR NR NR NR
W (warfarin) 67 41.8 69.5 (9.5) 17.9 1.5
A (aspirin) 86 41.9 73.0 (10.0) 25.6 4.7
C (no antithrombotic therapy) 118 38.1 69.4 (12.7) 10.2 0.8
Shen 2015 [28] US, USRDS national registry 4 All patients with HD who had a new diagnosis of AF based on 1 inpatient or 2 outpatient diagnosis codes T (total) 12284 NR NR NR NR
W (warfarin) 1838 50.3 61.2 (12.4) NR NR
C (no warfarin) 10446 51.3 62.1 (13.6) NR NR
Wang 2015 [14] New Zealand, single center 9 Patients with ESRD commenced on long-term dialysis at a hospital who had pre-existing or developed AF, includes prevalent warfarin users T (total) 141 38.3 61.2 (11.3) NR 19.1
W (warfarin) 59 39.0 59.8 (10.5) NR 16.9
C (no warfarin) 82 37.8 62.1 (11.8) NR 20.7
Yodogawa 2015 [35] Japan, single center 9.5 Patients aged ≥ 20 years with AF and ESRD requiring maintenance HD, includes prevalent warfarin users T (total) 84 30 NR 5 6
W (warfarin) 30 20 69.5 (10.7) 10 3
C (no warfarin) 54 35 70.4 (10.2) 2 7
Findlay 2016 [15] UK, single center 7 Adult patients receiving hemodialysis, exclude those treated for acute kidney injury, includes prevalent warfarin users T (total) 293 NR NR NR NR
W (warfarin) 118 NR NR NR NR
C (no warfarin) 175 NR NR NR NR
Tanaka 2016 [16] Japan, multi-center 2.5 Patients with ESRD with dialysis initiation who became stable and were discharged from hospital with or without AF, includes prevalent warfarin users T (total) 93 37.6 NR NR NR
W (warfarin) 46 26.1 73.6 (8.5) 19.6 6.5
C (no warfarin) 47 34.0 70.7 (12.1) 8.5 0.0
  1. AF atrial fibrillation, HD hemodialysis, PD peritoneal dialysis, CKD chronic kidney disease, ESRD end stage renal disease, RRT renal replacement therapy, NR not reported
  2. A all relevant patients with ESRD and AF included in study, T patients with ESRD and AF in the treatment group, C patients with ESRD and AF in the comparison group
  3. a Data were abstracted from the online supplement
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