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Table 7 Uni- and multivariate Cox survival analysis

From: Prognosis of patients with severe hyponatraemia is related not only to hyponatraemia but also to comorbidities and to medical management: results of an observational retrospective study

 

Univariate Cox analysis

HR [95CI]

P

Multivariate Cox analysisa

HR [95CI]

P

Male vs. Female

0.57 [0.36–0.90]

.02

0.69 [0.40–1.20]

.19

Age

0.99 [0.97–1.01]

.37

  

Hospital vs. community-acquired hyponatraemia

2.24 [1.41–3.56]

.001

1.23 [0.67–2.27]

.51

Chronic vs. acute hyponatraemia

0.72 [0.28–1.85]

.50

  

Symptomatic hyponatraemia

0.80 [0.51–1.27]

.36

  

Severe neurologic symptoms

0.85 [0.37–1.97]

.71

  

Nadir of plasma sodium

1.02 [0.97–1.08]

.35

0.95 [0.89–1.01]

.13

Urine analysis

0.64 [0.39–1.06]

.08

0.48 [0.27–0.85]

.01

Absence of diagnosis

1.77 [1.11–2.81]

.02

1.07 [0.55–2.07]

.84

Number of potential causes

1.45 [1.23–1.70]

<.001

1.07 [0.84–1.35]

.59

Treatment for hyponatraemia

0.34 [0.19–0.60]

<.001

0.67 [0.30–1.52]

.34

Accuracy of treatment

0.95 [0.43–2.08]

.90

  

Plasma sodium normalisation

0.61 [0.39–0.97]

.04

0.35 [0.20–0.62]

<.001

Excessive correction

0.64 [0.33–1.25]

.19

0.76 [0.33–1.77]

.52

Charlson comorbidity index

1.28 [1.19–1.38]

<.001

1.23 [1.13–1.34]

<.001

Serum albumin (g/l)

0.91 [0.88–0.95]

<.001

0.88 [0.84–0.92]

<.001

  1. HR Hazard ratio, 95CI: 95 % confidence interval. aThe multivariate model included the clinical relevant parameters and those with a P-value less than 0.2 in univariate analysis