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Table 5 Predictor of HOMA index at study completion by unadjusted and multivariable adjusted spline regression analyses

From: Correction of metabolic acidosis improves insulin resistance in chronic kidney disease

Predictor of HOMA index at study completion (further elaborations)

Variable

B-coef

Standard Error

P value

Unadjusted

- Serum bicarbonate <28 mmol/l at follow-up

−4.6008

1.1804

0.00015

- Serum bicarbonate ≥28 mmol/l at follow-up

1.9360

1.0270

0.06146

Adjusted for treatment, serum bicarbonate greater/equal or lower than 28 mmol/l

- Treatment (yes vs no)

−0.3482

0.4757

0.4654

- Serum bicarbonate <28 mmol/l at follow-up

−3.6980

1.7085

0.0321

- Serum bicarbonate ≥28 mmol/l at follow-up

2.2055

1.0926

0.0454

  1. Serum bicarbonate is used as a continuous variable and divided according to ≥ 28 mmol/l (knot). The HOMA-serum bicarbonate levels relationship changes for values of serum bicarbonate greater equal than 28 mmol/l