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Table 3 Odds ratios for renal hyperfiltration using alternative renal hyperfiltration definitions and variable models

From: Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study

 

Model 1

Model 2

Model 3

Model 4

 

OR

CI

P

OR

CI

P

OR

CI

P

OR

CI

P

RHFHeight

 BMI < 25 kg/m2

1.00

(ref)

 

1.00

(ref)

 

1.00

(ref)

 

1.00

(ref)

 

 BMI 25–30 kg/m2

2.54

(1.45–4.47)

0.001

2.40

(1.36–4.24)

0.002

2.27

(1.28–4.05)

0.005

2.22

(1.24–3.95)

0.007

 BMI > 30 kg/m2

8.03

(4.50–14.33)

<0.001

7.19

(3.99–12.94)

<0.001

6.11

(3.27–11.44)

<0.001

5.85

(3.12–10.99)

<0.001

 BMI per 5 kg/m2a

2.66

(2.13–3.32)

<0.001

2.54

(2.02–3.19)

<0.001

2.40

(1.87–3.09)

<0.001

2.35

(1.83–3.03)

<0.001

 WC < 80/94 cm

1.00

(ref)

 

1.00

(ref)

 

1.00

(ref)

 

1.00

(ref)

 

 WC 80–88/94–102 cm

1.89

(0.93–3.85)

0.08

1.82

(0.89–3.72)

0.10

1.63

(0.79–3.35)

0.18

1.62

(0.79–3.32)

0.19

 WC > 88/102 cm

4.96

(2.59–9.49)

<0.001

4.48

(2.32–8.62)

<0.001

3.64

(1.86–7.14)

<0.001

3.52

(1.79–6.91)

<0.001

 WC per 10 cma

1.99

(1.68–2.35)

<0.001

1.92

(1.62–2.27)

<0.001

1.80

(1.50–2.17)

<0.001

1.78

(1.47–2.14)

<0.001

 WHR < 0,85/0,90

1.00

(ref)

 

1.00

(ref)

 

1.00

(ref)

 

1.00

(ref)

 

 WHR > 0,85/0,90

2.91

(1.75–4.83)

<0.001

2.66

(1.59–4.43)

<0.001

2.24

(1.33–3.78)

0.002

2.17

(1.28–3.66)

0.004

 WHR per 0.10a

2.67

(1.98–3.60)

<0.001

2.49

(1.84–3.37)

<0.001

2.20

(1.60–3.02)

<0.001

2.14

(1.55–2.94)

<0.001

RHFWeight/height

 BMI < 25 kg/m2

1.00

(ref)

 

1.00

(ref)

 

1.00

(ref)

 

1.00

(ref)

 

 BMI 25–30 kg/m2

0.84

(0.55–1.28)

0.42

0.79

(0.52–1.21)

0.28

0.72

(0.47–1.12)

0.14

0.70

(0.45–1.09)

0.11

 BMI > 30 kg/m2

1.17

(0.72–1.90)

0.53

1.04

(0.63–1.71)

0.88

0.84

(0.49–1.45)

0.53

0.80

(0.46–1.39)

0.43

 BMI per 5 kg/m2a

1.14

(0.92–1.42)

0.24

1.08

(0.86–1.36)

0.50

0.97

(0.75–1.26)

0.82

0.95

(0.73–1.23)

0.70

 WC < 80/94 cm

1.00

(ref)

 

1.00

(ref)

 

1.00

(ref)

 

1.00

(ref)

 

 WC 80–88/94–102 cm

1.23

(0.72–2.10)

0.44

1.20

(0.70–2.04)

0.50

1.12

(0.65–1.92)

0.69

1.11

(0.65–1.91)

0.70

 WC > 88/102 cm

1.56

(0.95–2.56)

0.08

1.44

(0.87–2.38)

0.16

1.29

(0.76–2.19)

0.35

1.25

(0.73–2.13)

0.41

 WC per 10 cma

1.21

(1.03–1.42)

0.02

1.17

(0.99–1.38)

0.07

1.11

(0.92–1.33)

0.28

1.09

(0.91–1.31)

0.35

 WHR < 0,85/0,90

1.00

(ref)

 

1.00

(ref)

 

1.00

(ref)

 

1.00

(ref)

 

 WHR > 0,85/0,90

1.66

(1.07–2.55)

0.02

1.57

(1.01–2.42)

0.04

1.45

(0.93–2.27)

0.10

1.42

(0.90–2.22)

0.13

 WHR per 0.10a

1.66

(1.24–2.21)

<0.001

1.59

(1.18–2.13)

0.002

1.51

(1.11–2.06)

0.009

1.48

(1.08–2.02)

0.01

  1. RHF Renal hyperfiltration, OR Odds ratio, CI Confidence interval, BMI Body mass index, WC Waist circumference, WHR Waist-hip ratio
  2. Model 1: Adjustment for age, sex, number of cigarettes smoked daily, ambulatory daytime systolic and diastolic BP (and their interaction), and individual categories of antihypertensive medication
  3. Model 2: Model 1 and a dichotomous variable for a metabolically unhealthy lipid profile, defined as HDL-cholesterol levels < 1.03 mmol/L in men or < 1.29 mmol/L in women, elevated triglyceride levels of ≥ 1.7 mmol/L, and/or use of lipid-lowering medication
  4. Model 3: Model 1 plus fasting plasma glucose and insulin levels, and HOMA-IR
  5. Model 4: All models combined
  6. acontinuous variable
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BMC Nephrology

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