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Table 3 Pearson correlation matrix of metabolites and clinical data (n = 27)

From: Tryptophan metabolism, its relation to inflammation and stress markers and association with psychological and cognitive functioning: Tasmanian Chronic Kidney Disease pilot study

 

Neopterin

Cortisol

Tryptophan

Serotonin (5-HT)

5-OH IAA

5-OH IAA/5-HT

Kynurenine

KYN/TRP

Kynurenic acid

Quinolinic acid

Xanthurenic acid

Quinaldic acid

3-OH anthranilic acid

Indoxyl sulfate

IAA

A) Clinical

Age

−0.17

−0.34

0.46*

−0.03

−0.55**

−0.26

−0.37

−0.44*

0.02

−0.15

0.19

−0.23

−0.22

−0.24

0.17

BMI

−0.23

0.32

−0.27

−0.10

−0.05

0.06

−0.25

0.03

0.06

0.14

−0.21

−0.26

−0.19

−0.18

−0.30

Serum creatinine

0.65***

−0.15

−0.10

0.04

0.66***

0.31

0.53**

0.71***

0.17

0.43*

0.12

0.71***

0.63***

0.78***

0.04

eGFR

−0.56**

0.07

0.16

0.001

−0.67***

−0.35

−0.46*

−0.64***

−0.11

−0.41*

−0.01

−0.63***

−0.51**

−0.71***

0.12

B) Metabolites

Neopterin

1

              

Cortisol

−0.13

1

             

Tryptophan

0.12

−0.29

1

            

Serotonin (5-HT)

0.11

−0.06

−0.05

1

           

5-OH IAA

0.50**

0.05

−0.37

−0.02

1

          

5-OH IAA/5-HT

0.17

0.08

−0.15

−0.86***

0.53**

1

         

Kynurenine

0.60***

−0.28

0.56**

−0.03

0.39*

0.21

1

        

KYN/TRP

0.55**

−0.04

−0.45*

0.03

0.83***

0.40*

0.46*

1

       

Kynurenic acid

0.26

0.06

0.11

−0.16

0.07

0.18

0.32

0.17

1

      

Quinolinic acid

0.52**

−0.01

0.05

−0.04

0.33

0.20

0.49**

0.44*

0.05

1

     

Xanthurenic acid

0.21

−0.09

0.56**

0.005

−0.18

−0.10

0.37

−0.20

−0.05

0.39*

1

    

Quinaldic acid

0.67***

0.05

0.05

0.10

0.64***

0.25

0.60***

0.61***

0.37

0.23

0.10

1

   

3-OH Anth acid

0.71***

0.003

0.13

0.11

0.35

0.09

0.57**

0.46*

0.48*

0.49**

0.30

0.75***

1

  

Indoxyl sulfate

0.68***

−0.15

−0.23

0.09

0.58**

0.22

0.44*

0.69***

0.22

0.50**

−0.06

0.71***

0.63***

1

 

IAA

0.07

0.10

0.17

−0.20

0.01

0.17

0.24

0.07

0.14

0.05

0.22

0.09

0.20

−0.07

1

  1. Abbreviations: 5-HT serotonin, Anth anthranilic, BMI body mass index, eGFR estimated glomerular filtration rate, IAA indole-3-acetic acid, KYN kynurenine, TRP tryptophan
  2. Significance levels: *P < 0.05; **P < 0.01; ***P < 0.001