Skip to main content
Fig. 5 | BMC Nephrology

Fig. 5

From: Alteration of histone H3K4 methylation in glomerular podocytes associated with proteinuria in patients with membranous nephropathy

Fig. 5

Podocyte swelling and the expression of H3K4 me3 and synaptopodin in the LPS model. Electron microscopy reveals podocyte swelling induced by LPS administration (right side in a and d) compared with the controls (vehicle alone, left side in a and d). The expression of histone H3K4 me3 was significantly higher following LPS administration (right side in b and e) than in the controls (vehicle alone, left side in b and e). Synaptopodin expression was significantly lower following LPS administration (right side in c and f) compared to that of the controls (vehicle alone, left side in c and f). *P < 0.05 vs. Veh. LPS, lipopolysaccharide treated mice; Veh, vehicle treated mice; H3K4 me3, histone H3K4 trimethylation; N = 10. Data are expressed as the mean ± SE

Back to article page