Table 1 General characteristics of the study population

Age, years

9.9 ± 4.4

10.5 ± 4.3

9.0 ± 4.4

Hb, g/dl

8.2 ± 1.3

7.9 ± 1.3

8.6 ± 1.4

Leukocytes, elts/mm³

11618 ± 4621

11339 ± 4114

12011 ± 5113

Platelets, elts/mm³

380727 ± 154522

364.358 ± 132.846

401.884 ± 184.553

Reticulocytes, %

12.0 (8.5–17.6)

11,0 (7,0–15,5)

14,0 (9,6–19,8)

HbF, %

8.7 (3.5–16.9)

13.9 (6.9–21.4)

6.2 (2.1–9.7)

Patients receiving HU, %

37

21

16

HbF in patients receiving HU, %

14 (7–21)

11 (6–18)

19 (13–25)

Indirect Bilirubin, mg/dl

1.9 (0.9–3.5)

1.5 (0.9–3.8)

1.9 (1.1–3.5)

Total Bilirubin, mg/dl

2.5 (1.5–4.0)

2.2 (1.3–4.3)

2.6 (1.7–4.0)

Creatinine, mg/dl

0.38 ± 1.05

0.38 ± 0.12

0.37 ± 0.11

GFR, ml/min/1.73 m²

211 ± 54

209 ± 67

215 ± 35

LDH, UI/l

544 (400–771)

457 (338–761)

653 (490–788)

CPR, mg/l

3.4 (2.0–5.1)

3.0 (1.3–4.5)

3.9 (2.8–6.9)

Iron, micromol/l

16.2 (13.2–19.2)

16.3 (14.0–21.1)

15.5 (11.5–17.8)

Ferritin, ng/ml

209 (106–453)

301 (111–613)

184 (104–378)

Free plasmatic Hb, mg/l

168 (116–267)

140 (120–240)

210 (106–288)

Cu-Zn SOD, pg/ml

305 (112–556)

281 (96–426)

360 (130–657)

GPx, micromol/l

220 (100–476)

242 (107–549)

210 (93–466)

UACR, mg/g

12 (9–22)

10 (9–20)

18 (10–26)