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Table 2 IF and EM findings in patients with psoriasis and membranous nephropathy

From: PLA2R antibodies and PLA2R glomerular deposits in psoriasis patients with membranous nephropathy

Case

IF findings

 

Electron microscopy findings

IgG

IgA

IgM

C3

C1q

PLA2R

IgG subtyping

Subepithelial deposits

Subendothelial deposits

Mesangial deposits

Stage of MN

1

1+

1+

1+

1+

1+

Neg

IgG1 1+ , IgG2 1+, IgG4 2+

ND

ND

ND

ND

2

2+

1+

Neg

2+

Neg

Neg

IgG1 2+ , IgG2 1+, IgG4 1+

ND

ND

ND

ND

3

1+

Neg

1+

1+

1+

Neg

IgG1 2+, IgG4 2+

ND

ND

ND

ND

4

2+

1+

1+

2+

Neg

Neg

IgG1 2+, IgG4 2+

ND

ND

ND

ND

5

2+

1+

Neg

2+

Neg

Neg

IgG1 2+ , IgG2 1+, IgG4 2+

+

Neg

Neg

2

6

4+

1+

1+

2+

1+

Neg

IgG1 2+, IgG4 1+

+

Neg

Neg

2

7

2+

Neg

Neg

1+

Neg

Neg

IgG1 2+ , IgG2 1+, IgG4 2+

+

+

+

2

8

2+

Neg

Neg

2+

1+

Neg

IgG1 2+ , IgG2 1+, IgG4 1+

+

Neg

Neg

2

9

2+

1+

Neg

1+

Neg

Neg

IgG1 2+, IgG4 2+

+

Neg

+

3

10

2+

Neg

Neg

2+

1+

Neg

IgG1 2+ , IgG2 1+, IgG4 2+

+

Neg

+

1

11

2+

Neg

Neg

2+

1+

Neg

IgG1 2+ , IgG2 1+, IgG4 1+

+

+

+

1

12

2+

1+

1+

2+

1+

+

IgG1 1+ , IgG2 1+, IgG4 2+

+

Neg

Neg

3

13

2+

Neg

Neg

1+

1+

+

IgG1 1+, IgG2 1+, IgG3 1+, IgG4 2+

+

Neg

+

3

14

2+

Neg

Neg

2+

Neg

Neg

IgG1 2+, IgG4 1+

+

Neg

Neg

1

15

2+

Neg

Neg

1+

Neg

+

No glomeruli

+

Neg

Neg

3

16

2+

Neg

Neg

Neg

Neg

Neg

IgG1 1+ , IgG2 1+, IgG4 2+

+

Neg

+

2

17

2+

1+

1+

1+

1+

Neg

IgG1 2+ , IgG2 1+, IgG4 1+

+

Neg

+

3

18

2+

Neg

Neg

2+

1+

+

IgG1 1+ , IgG2 1+, IgG4 2+

+

Neg

Neg

2

19

2+

2+

Neg

1+

Neg

+

IgG1 2+ , IgG2 1+, IgG4 2+

+

Neg

+

3

20

2+

Neg

Neg

2+

1+

+

IgG1 2+, IgG2 1+, IgG3 1+, IgG4 3+

+

Neg

Neg

2

21

2+

Neg

Neg

2+

Neg

+

IgG1 1+, IgG2 1+, IgG3 2+, IgG4 2+

+

+

+

3

22

2+

Neg

1+

2+

Neg

Neg

IgG1 2+, IgG4 2+

+

Neg

Neg

2

23

2+

Neg

Neg

2+

Neg

Neg

IgG1 3+, IgG2 2+, IgG3 1+, IgG4 2+

+

Neg

Neg

1

24

2+

Neg

Neg

2+

Neg

Neg

IgG1 2+ , IgG2 1+, IgG4 2+

+

Neg

Neg

3