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Fig. 2 | BMC Nephrology

Fig. 2

From: Urinary exosomal activating transcriptional factor 3 as the early diagnostic biomarker for sepsis-induced acute kidney injury

Fig. 2

Survival analysis of the cecal ligation and puncture (CLP) model used in the study (a) and time-course of serum neutrophil gelatinase associated lipocalin (sNGAL) and serum creatinine (Scr) (b) were demonstrated. The representative pictures of the immunohistochemistry of mouse kidney after 6 h of CLP sepsis surgery for NGAL (c) and activating transcriptional factor 3 (ATF3) (d). NGAL and ATF3 were demonstrated in cytoplasm/brush border and nuclei of cortical renal tubules cells, respectively, and both parameters could not be detected in kidney of sham surgery (data not showed). Additionally, activated caspase-3 was also analyzed in kidney sample at 6 h of CLP and sham surgery (e). The comparison of Caspase-3 Western Blot density between kidney of sham and CLP group measured from C-DiGit® Blot Scanner was also showed (f)

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BMC Nephrology

ISSN: 1471-2369

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