Urinary exosomal activating transcriptional factor 3 as the early diagnostic biomarker for sepsis-induced acute kidney injury

Table 4 Net classification for model improvement with urine neutrophil gelatinase-associated lipocalin (uNGAL) and urine exosomal activating transcriptional factor 3 (uATF3)

Sepsis-AKI	+ uNGAL	+ uATF3	+ uNGAL + uATF3
Goodness-of-fit reference	0.69	0.83	0.88
Goodness-of-fit reference + biomarker (s)	0.75	0.86	0.84
AUROC of reference	0.61 (0.55 – 0.63)	0.74 (0.71-0.78)	0.84 (0.80 – 0.88)
AUROC of reference + biomarker (s)	0.64 (0.54-0.74)	0.84 (0.77-0.91)	0.85 (0.81 – 0.90)
P-value (AUC difference)	=0.03	<0.0001	=0.11
cfNRI [events; % (CI)]	47.1 (33.9 – 69.8)	69.3 (66.4 – 82.8)	49.2 (25.5 – 56.8)
cfNRI [non-event; % (CI)]	34.8 (25.4 – 52.3)	44.4 (30.8 – 51.0)	51.8 (43.4 – 58.9)
cfNRI [% (CI)]	74.9 (63.7 – 88.9)	82.5 (74.8 – 90.1)	79.7 (70.8 – 88.8)

The reference is the multiple regression model with age, comorbidity and APACHE II score with uNGAL and uATF3. The calibration of the model was performed by using Hosmer–Lemeshow goodness-of-fit test. AUROC, area under the receiver operating characteristic curve; cfNRI, category-free net reclassification improvement; CI, 95% confidence interval; uATF3, urinary activating transcriptional factor 3; uNGAL, urinary neutrophil gelatinase-associated lipocalin

ISSN: 1471-2369