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Table 4 Net classification for model improvement with urine neutrophil gelatinase-associated lipocalin (uNGAL) and urine exosomal activating transcriptional factor 3 (uATF3)

From: Urinary exosomal activating transcriptional factor 3 as the early diagnostic biomarker for sepsis-induced acute kidney injury

Sepsis-AKI + uNGAL + uATF3 + uNGAL + uATF3
Goodness-of-fit reference 0.69 0.83 0.88
Goodness-of-fit reference + biomarker (s) 0.75 0.86 0.84
AUROC of reference 0.61 (0.55 – 0.63) 0.74 (0.71-0.78) 0.84 (0.80 – 0.88)
AUROC of reference + biomarker (s) 0.64 (0.54-0.74) 0.84 (0.77-0.91) 0.85 (0.81 – 0.90)
P-value (AUC difference) =0.03 <0.0001 =0.11
cfNRI [events; % (CI)] 47.1 (33.9 – 69.8) 69.3 (66.4 – 82.8) 49.2 (25.5 – 56.8)
cfNRI [non-event; % (CI)] 34.8 (25.4 – 52.3) 44.4 (30.8 – 51.0) 51.8 (43.4 – 58.9)
cfNRI [% (CI)] 74.9 (63.7 – 88.9) 82.5 (74.8 – 90.1) 79.7 (70.8 – 88.8)
  1. The reference is the multiple regression model with age, comorbidity and APACHE II score with uNGAL and uATF3. The calibration of the model was performed by using Hosmer–Lemeshow goodness-of-fit test. AUROC, area under the receiver operating characteristic curve; cfNRI, category-free net reclassification improvement; CI, 95% confidence interval; uATF3, urinary activating transcriptional factor 3; uNGAL, urinary neutrophil gelatinase-associated lipocalin