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Table 5 Cox uncensored graft loss, uni- and multivariable model

From: Should patients older than 65 years be offered a second kidney transplant?

 

Univariable

Multivariable

 

HR

95% CI

P

HR

95% CI

P

TX2

1.06

0.68-1.67

0.789

1.24

0.77-2.00

0.375

Recipient age

1.07

1.04-1.09

<0.001

1.06

1.03-1.09

<0.001

Male recipient

1.20

0.95-1.53

0.132

1.09

0.85-1.40

0.510

Coronary heart disease

1.15

0.91-1.45

0.247

   

Diabetes mellitusa

1.21

0.93-1.57

0.160

1.08

0.80-1.45

0.607

Cerebrovascular disease

1.27

0.92-1.75

0.143

1.14

0.81-1.59

0.462

Peripheral vascular disease

1.23

0.96-1.58

0.106

0.97

0.74-1.28

0.840

Time on dialysis (months)b

1.02

1.01-1.02

<0.001

1.02

1.01-1.03

<0.001

Pre-emptive transplantationb

0.74

0.54-1.02

0.063

0.67

0.42-1.08

0.106

HD vs. PD

1.27

0.95-1.70

0.101

1.27

0.83-1.93

0.278

Donor agec

1.02

1.01-1.02

<0.001

1.02

1.01-1.02

<0.001

Donor > 60 yearsc

1.54

1.24-1.91

<0.001

1.57

1.23-2.00

<0.001

Male donor

0.97

0.79-1.20

0.800

   

CMV positive donor

1.23

0.97-1.58

0.094

1.06

0.81-1.39

0.664

CMV positive recipient

0.81

0.63-1.06

0.119

0.86

0.66-1.13

0.285

Cold ischemia time (CIT)

1.00

0.98-1.02

0.957

   

Any HLA-A mismatch

0.78

0.60-1.00

0.05

0.73

0.56-0.96

0.025

Any HLA-B mismatch

1.28

0.91-1.80

0.160

1.42

0.98-2.07

0.066

Any HLA-DR mismatch

1.23

0.99-1.51

0.061

1.00

0.79-1.26

0.998

Induction therapy

0.82

0.66-1.03

0.089

0.67

0.52-0.87

0.003

CNI

0.88

0.55-1.42

0.605

   

CSA vs. Tacrolimus

1.14

0.80-1.64

0.477

   

MMF

0.77

0.55-1.08

0.123

0.61

0.42-0.90

0.011

mTOR

0.51

0.21-1.24

0.137

0.63

0.26-1.54

0.307

PRA positive

0.93

0.58-1.49

0.752

   

Any acute rejection

1.11

0.87-1.42

0.393

   

Glomerulonepritis

0.68

0.53-0.89

0.005

0.63

0.45-0.89

0.008

Pyelonephritis

0.90

0.56-1.47

0.687

0.65

0.37-1.13

0.124

Polycystic kidney disease

0.80

0.58-1.10

0.172

0.68

0.46-1.02

0.064

Vascular nephropathy

1.24

1.00-1.44

0.051

0.87

0.64-1.18

0.373

Diabetes nephropathya

1.31

0.91-1.90

0.151

1.01

0.64-1.59

0.970

  1. aDiabetes and diabetes nephropathy were tested i separate multivariable models. Diabetes was selected in the final model
  2. bPre-emptive transplantation and time on dialysis/dialysis mode were tested in separate multivariable models. In the final model, pre-emptive transplantation was excluded
  3. cDonor > 60 years and Donor age were tested in separate multivariable models. Only the continuous variable Donor age was included in the final model
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BMC Nephrology

ISSN: 1471-2369

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