Table 3 Factors predicting remission of nephrotic syndrome after tacrolimus treatment in univariate and multivariate logistic model
From: Evaluating tacrolimus treatment in idiopathic membranous nephropathy in a cohort of 408 patients
Variables | Partial or complete remission | Complete remission | ||||
|---|---|---|---|---|---|---|
OR | 95% CI | P-Value | OR | 95% CI | P-Value | |
Univariate logistic models | ||||||
Gender (Female vs. Male) | 1.6 | 0.99–2.6 | 0.06 | 3.1 | 1.9–4.9 | <0.001 |
eGFR at baseline (for every 10 mL/min/1.73 m2) | 1.1 | 1.0–1.2 | 0.003 | 1.1 | 1.0–1.2 | 0.06 |
Proteinuria at the onset of tacrolimus therapy | 0.94 | 0.87–1.0 | 0.11 | 0.94 | 0.86–1.0 | 0.22 |
Previous treated with immunosuppressive drugs (Yes vs. No) | 0.42 | 0.25–0.70 | <0.001 | 0.42 | 0.19–0.85 | 0.02 |
Average tacrolimus exposure (ng/mL) | 1.2 | 1.1–1.3 | 0.004 | 1.2 | 1.0–1.3 | 0.005 |
Multivariate logistic model | ||||||
Gender (Female vs. Male) | 1.7 | 1.0–3.0 | 0.04 | 3.3 | 2.0–5.6 | <0.001 |
Previous treatment with immunosuppressive drugs (Yes vs. No) | 0.39 | 0.22–0.67 | <0.001 | 0.40 | 0.17–0.83 | 0.02 |
eGFR at baseline (for every 10 mL/min/1.73 m2) | 1.2 | 1.1–1.4 | 0.001 | 1.1 | 0.99–1.2 | 0.07 |
Average tacrolimus exposure (ng/mL) | 1.2 | 1.1–1.3 | 0.001 | 1.2 | 1.0–1.2 | <0.001 |