Protective effect of quinacrine against glycerol-induced acute kidney injury in rats

BMC Nephrology

Table 2 Effect of quinacrine on glycerol-induced AKI; level of serum electrolytes and phosphorus

Groups	Calcium mg/dL	Magnesium mg/dL	Sodium mmol/L	Potassium mmol/L	Phosphorus mg/dL
Control	9.21 ± 0.123	1.76 ± 0.111	140 ± 4.4	3.96 ± 0.25	5.98 ± 0.119
GLY 25%	9.73 ± 0.164 ##	3.23 ± 0.237###	135 ± 3.7	5.46 ± 0.302#	7.53 ± 0.588#
QRN 3 mg/kg + GLY	9.27 ± 0.164 *	2.45 ± 0.206*	136 ± 4.0	5.15 ± 0.302	6.68 ± 0.706
QRN 10 mg/kg + GLY	9.12 ± 0.104***	2.33 ± 0.155**	143 ± 6.8	4.2 ± 0.401	5.86 ± 0.676
QRN 30 mg/kg + GLY	9.00 ± 0.004***	2.03 ± 0.113***	151 ± 5.6*	3.85 ± 0.241**	4.8 ± 0.311***

Single intramuscular glycerol injection significantly increase the level of serum calcium, magnesium, potassium, phosphorus and lowered the level of sodium, whereas quinacrine treatment attenuate this alteration in serum electrolytes. Data expressed as mean ± SE. # P < 0.05, ## P < 0.01and ### P < 0.001 as compare with control group. *P < 0.05, **P < 0.01 and *** P < 0.001 as compare to glycerol treated group

ISSN: 1471-2369