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Table 3 Effect of quinacrine on glycerol induced body weight, kidney weight and kidney weight to body weight ratio

From: Protective effect of quinacrine against glycerol-induced acute kidney injury in rats

 

Body weight (gm)

Kidney weight (gm)

KW /BW ratio

Control

209.5 ± 2.34

0.651 ± 0.020

0.309 ± 0.010

GLY 25%

196.8 ± 3.28

1.481 ± 0.041#

0.755 ± 0.031#

QRN 3 mg/kg + GLY

193.6 ± 3.17

1.302 ± 0.067*

0.694 ± 0.036

QRN 10 mg/kg + GLY

195.5 ± 2.86

1.293 ± 0.047**

0.634 ± 0.038*

QRN 30 mg/kg + GLY

198.6 ± 3.01

1.017 ± 0.059***

0.525 ± 0.029***

  1. Effect of quinacrine on glycerol induced changes in kidney weight and body weight. The body weight was not change in all the treated groups but the kidney weight and KW/BW ratio significantly increased in glycerol treated groups. Quinacrine treatment showed a significant and dose dependent attenuation of glycerol induced increase in KW and KW/BW ratio. Data expressed as mean ± SE. # P < 0.001 as compare with control group and *P < 0.05, ** P < 0.01 and *** P < 0.001 as compared with Glycerol treated group