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Table 3 Effect of quinacrine on glycerol induced body weight, kidney weight and kidney weight to body weight ratio

From: Protective effect of quinacrine against glycerol-induced acute kidney injury in rats

  Body weight (gm) Kidney weight (gm) KW /BW ratio
Control 209.5 ± 2.34 0.651 ± 0.020 0.309 ± 0.010
GLY 25% 196.8 ± 3.28 1.481 ± 0.041# 0.755 ± 0.031#
QRN 3 mg/kg + GLY 193.6 ± 3.17 1.302 ± 0.067* 0.694 ± 0.036
QRN 10 mg/kg + GLY 195.5 ± 2.86 1.293 ± 0.047** 0.634 ± 0.038*
QRN 30 mg/kg + GLY 198.6 ± 3.01 1.017 ± 0.059*** 0.525 ± 0.029***
  1. Effect of quinacrine on glycerol induced changes in kidney weight and body weight. The body weight was not change in all the treated groups but the kidney weight and KW/BW ratio significantly increased in glycerol treated groups. Quinacrine treatment showed a significant and dose dependent attenuation of glycerol induced increase in KW and KW/BW ratio. Data expressed as mean ± SE. # P < 0.001 as compare with control group and *P < 0.05, ** P < 0.01 and *** P < 0.001 as compared with Glycerol treated group