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Table 2 List of proteins identified in urine from training set using peptide mass fingerprinting

From: Comparative differential proteomic analysis of minimal change disease and focal segmental glomerulosclerosis

# Spota P-value MCD FSGS Foldb Trendc Protein name Gene name UniProt accession no.d Seq. Cov. (%) Matched peptides MASCOT Score
1,064 0.004 0.39 1.67 4.3 Down Branched-chain-amino-acid aminotransferase, mithocondrial BCAT2 O15382 19.9 5 42.4
1,070 0.004 0.18 2.04 11.5 Down Nuclear inhibitor of protein phosphatase I PPP1R8 Q12972 28.2 7 48.4
1,334 <0.001 1.79 0.44 4.1 Up Alpha-1-antitrypsin SERPINA1 P01009 21.3 6 44.6
       Platelet-activating factor receptor PTAFR P25105 17.3 5 46.5
       Cyclin-Y CCNY Q8ND76 32.6 7 49.8
1,352 <0.001 1.79 0.43 4.2 Up Alpha-1-antitrypsin SERPINA1 P01009 49.3 13 51.7
1,354 <0.001 1.77 0.40 4.5 Up Alpha-1-antitrypsin SERPINA1 P01009 49.3 18 86.3
       Transmembrane channel-like protein 1 TMC1 Q8TDI8 23.9 15 33.4
1,356 <0.001 1.85 0.38 4.8 Up Transcription elongation factor 1 homolog ELOF1 P60002 51.8 7 36.2
1,363 <0.001 1.51 0.59 2.6 Up Transferrin TF P02787 24.5 12 64.9
1,392 0.01 0.31 1.57 5.1 Down Serum albumin ALB P02768 28.1 16 58.6
       Leucine-rich repeat-containing protein C10orf11 c10orf11 Q9H2I8 36.9 6 41.6
1,400 0.005 2.18 0.38 5.7 Up Serum albumin ALB P02768 39.4 21 85.1
1,408 0.006 2.17 0.49 4.4 Up Serum albumin ALB P02768 53.2 31 92.1
1,458 0.002 0.28 1.69 6.1 Down PEST proteolytic signal-containing nuclear protein PCNP Q8WW12 51.7 5 38.6
       Branched-chain -amino-acid aminotransferase, mithocondrial BCAT2 O15382 19.9 5 42.4
1,460 <0.001 0.25 1.72 7 Down Leucine-rich repeat-containing protein C10orf11 c10orf11 Q9H2I8 36 9 32.7
       Calretinin CALB2 P22676 32.1 7 27.9
1,468 <0.001 2.22 0.71 3.1 Up Serum albumin ALB P02768 24.8 21 80.2
       39S Ribosomal protein L17, mithocondrial MRPL17 Q9NRX2 62.9 9 40
       Humanin-like protein 6 HN6 P0CJ73 100 7 64.1
1,469 <0.001 2.98 0.68 4.4 Up Serum albumin ALB P02768 28.2 25 56.6
       Histatin-3 HTN3 P15516 68.6 4 36.7
7,740 <0.001 1.27 0.49 2.6 Up Zinc-alpha-2-glycoprotein AZGP1 P25311    155
7,810 <0.001 1.27 0.49 2.6 Up Zinc-alpha-2-glycoprotein AZGP1 P25311 28.9 10 61.9
  1. aSpot number generated by SameSpots image analysis software, referencing the spots shown on Additional file 2
  2. bRatio of protein expression between MCD and FSGS
  3. cUp: up-regulated in MCD compared to FSGS; Down: down-regulated in MCD compared to FSGS
  4. dAccession number from NCBInr database
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BMC Nephrology

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