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Table 2 List of proteins identified in urine from training set using peptide mass fingerprinting

From: Comparative differential proteomic analysis of minimal change disease and focal segmental glomerulosclerosis

# Spota

P-value

MCD

FSGS

Foldb

Trendc

Protein name

Gene name

UniProt accession no.d

Seq. Cov. (%)

Matched peptides

MASCOT Score

1,064

0.004

0.39

1.67

4.3

Down

Branched-chain-amino-acid aminotransferase, mithocondrial

BCAT2

O15382

19.9

5

42.4

1,070

0.004

0.18

2.04

11.5

Down

Nuclear inhibitor of protein phosphatase I

PPP1R8

Q12972

28.2

7

48.4

1,334

<0.001

1.79

0.44

4.1

Up

Alpha-1-antitrypsin

SERPINA1

P01009

21.3

6

44.6

      

Platelet-activating factor receptor

PTAFR

P25105

17.3

5

46.5

      

Cyclin-Y

CCNY

Q8ND76

32.6

7

49.8

1,352

<0.001

1.79

0.43

4.2

Up

Alpha-1-antitrypsin

SERPINA1

P01009

49.3

13

51.7

1,354

<0.001

1.77

0.40

4.5

Up

Alpha-1-antitrypsin

SERPINA1

P01009

49.3

18

86.3

      

Transmembrane channel-like protein 1

TMC1

Q8TDI8

23.9

15

33.4

1,356

<0.001

1.85

0.38

4.8

Up

Transcription elongation factor 1 homolog

ELOF1

P60002

51.8

7

36.2

1,363

<0.001

1.51

0.59

2.6

Up

Transferrin

TF

P02787

24.5

12

64.9

1,392

0.01

0.31

1.57

5.1

Down

Serum albumin

ALB

P02768

28.1

16

58.6

      

Leucine-rich repeat-containing protein C10orf11

c10orf11

Q9H2I8

36.9

6

41.6

1,400

0.005

2.18

0.38

5.7

Up

Serum albumin

ALB

P02768

39.4

21

85.1

1,408

0.006

2.17

0.49

4.4

Up

Serum albumin

ALB

P02768

53.2

31

92.1

1,458

0.002

0.28

1.69

6.1

Down

PEST proteolytic signal-containing nuclear protein

PCNP

Q8WW12

51.7

5

38.6

      

Branched-chain -amino-acid aminotransferase, mithocondrial

BCAT2

O15382

19.9

5

42.4

1,460

<0.001

0.25

1.72

7

Down

Leucine-rich repeat-containing protein C10orf11

c10orf11

Q9H2I8

36

9

32.7

      

Calretinin

CALB2

P22676

32.1

7

27.9

1,468

<0.001

2.22

0.71

3.1

Up

Serum albumin

ALB

P02768

24.8

21

80.2

      

39S Ribosomal protein L17, mithocondrial

MRPL17

Q9NRX2

62.9

9

40

      

Humanin-like protein 6

HN6

P0CJ73

100

7

64.1

1,469

<0.001

2.98

0.68

4.4

Up

Serum albumin

ALB

P02768

28.2

25

56.6

      

Histatin-3

HTN3

P15516

68.6

4

36.7

7,740

<0.001

1.27

0.49

2.6

Up

Zinc-alpha-2-glycoprotein

AZGP1

P25311

  

155

7,810

<0.001

1.27

0.49

2.6

Up

Zinc-alpha-2-glycoprotein

AZGP1

P25311

28.9

10

61.9

  1. aSpot number generated by SameSpots image analysis software, referencing the spots shown on Additional file 2
  2. bRatio of protein expression between MCD and FSGS
  3. cUp: up-regulated in MCD compared to FSGS; Down: down-regulated in MCD compared to FSGS
  4. dAccession number from NCBInr database
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BMC Nephrology

ISSN: 1471-2369

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