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Table 3 Variables independently associated with (A) plasma TF, (B) plasma suPAR, (C) endothelial dysfunctions markers, (D) Cu/Zn SOD, and neopterin levels in patients with CKD

From: Indoxyl sulfate – the uremic toxin linking hemostatic system disturbances with the prevalence of cardiovascular disease in patients with chronic kidney disease

  Independent variable Regression coefficient P value
A TF TM 0.489 0.007
Multiple R for variables in the model– 0.490, multiple R2 – 0.239, adjusted R2 – 0.211, p < 0.007
B suPAR uPA 0.418 <0.0001
hs-CRP 0.373 0.0002
neopterin 0.500 0.0012
lymphocytes −0.249 0.0046
TM 0.307 0.0084
sICAM-1 0.230 0.0171
vWF 0.157 0.0244
Cu/Zn SOD 0.156 0.0482
Multiple R for variables in the model – 0.985, multiple R2 – 0.971, adjusted R2 – 0.934, p < 0.0001
C vWF age 0.371 0.0104
F1 + 2 −0.276 0.0324
TM* PAP 0.497 0.0003
IS 0.426 0.0008
suPAR 0.399 0.0024
sVCAM-1^ IS 0.562 0.0007
sICAM-1 0.557 0.0008
neopterin 0.359 0.0140
sICAM-1# sVCAM-1 0.547 <0.0001
suPAR 0.357 0.0101
Multiple R for variables in the model – 0.633 (*0.863; ^0.960; #0.785), multiple R2 – 0.400 (*0.745; ^0.922; #0.617), adjusted R2 – 0.349 (*0.713; ^0.873; #0.574), all p < 0.0001
D Cu/Zn SOD IS 0.411 0.0031
TFPI 0.405 0.0071
sICAM-1 0.366 0.0093
F1 + 2 0.250 0.0442
neopterin* sVCAM-1 0.659 0.0010
TM 0.598 0.0062
TF 0.496 0.0100
IS 0.456 0.0119
Hemoglobin −0.324 0.0471
Multiple R for variables in the model – 0.655 (*0.926), multiple R2 – 0.429 (*0.857), adjusted R2 – 0.336 (*0.786), both p < 0.0001
  1. Abbreviations: TF tissue factor, TM thrombomodulin, suPAR soluble urokinase-type plasminogen activator receptor, uPA urinary plasminogen activator, hs-CRP high sensitivity C-reactive protein, sICAM-1 soluble intercellular adhesion molecule-1, vWF von Willebrand Factor, Cu/Zn SOD Cu/Zn superoxide dismutase 1, F1 + 2 prothrombin fragments 1 + 2, PAP plasmin-α2-antiplasmin, IS indoxyl sulfate, sVCAM-1 soluble vascular cell adhesion molecule-1, TFPI tissue factor pathway inhibitor; CKD – chronic kidney disease