Skip to main content

Table 5 The Spearman’s correlation between analyzed hemostatic parameters and the markers of monocyte activation (neopterin), oxidative stress (Cu/Zn SOD), inflammation (hs-CRP), and renal function (eGFR)

From: Indoxyl sulfate – the uremic toxin linking hemostatic system disturbances with the prevalence of cardiovascular disease in patients with chronic kidney disease

  Factor Neopterin (R /P value) Cu/Zn SOD (R/P value) Hs-CRP (R /P value) eGFR, (R /P value)
Coagulation TF 0.338 0.283 0.073 - 0.392
0.015 0.044 NS 0.004
F1 + 2 0.019 0.287 0.102 - 0.140
NS 0.041 NS NS
TFPI 0.179 0.325 0.325 - 0.402
NS 0.020 0.020 0.003
Fibrinolysis PAP 0.046 0.006 0.304 −0.027
NS NS 0.030 NS
uPA 0.179 0.287 0.247 - 0.329
NS 0.040 NS 0.018
suPAR 0.314 0.427 0.562 - 0.529
0.024 0.002 <0.0001 <0.0001
tPA −0.181 - 0.183 0.114 0.121
NS NS NS NS
PAI-1 −0.297 0.004 0.096 0.281
0.034 NS NS 0.046
Endothelial function vWF 0.076 0.165 0.330 - 0.172
NS NS 0.018 NS
TM 0.393 0.451 0.300 - 0.707
0.004 0.0008 0.033 <0.0001
sICAM-1 0.158 0.367 0.496 - 0.232
NS 0.008 0.0002 NS
sVCAM-1 0.527 0.448 0.467 - 0.569
<0.0001 0.0007 0.0006 <0.0001
  1. Results are shown as Spearman’s rank correlation coefficients (R) and its statistical significance (P values)
  2. Abbreviations: TF tissue factor, F1 + 2 prothrombin fragments 1 + 2, TFPI tissue factor pathway inhibitor, PAP plasmin-α2-antiplasmin, uPA urinary plasminogen activator, suPAR soluble urokinase-type plasminogen activator receptor, tPA tissue plasminogen activator, PAI-1 plasminogen activator inhibitor-1, vWF von Willebrand Factor, TM thrombomodulin, sICAM-1 soluble intercellular adhesion molecule-1, sVCAM-1 soluble vascular cell adhesion molecule-1, Cu/Zn SOD Cu/Zn superoxide dismutase 1, hs-CRP high sensitivity C-reactive protein, eGFR estimated glomerular filtration rate, NS non-significant