Indoxyl sulfate – the uremic toxin linking hemostatic system disturbances with the prevalence of cardiovascular disease in patients with chronic kidney disease

Table 5 The Spearman’s correlation between analyzed hemostatic parameters and the markers of monocyte activation (neopterin), oxidative stress (Cu/Zn SOD), inflammation (hs-CRP), and renal function (eGFR)

	Factor	Neopterin (R /P value)	Cu/Zn SOD (R/P value)	Hs-CRP (R /P value)	eGFR, (R /P value)
Coagulation	TF	0.338	0.283	0.073	- 0.392
	TF	0.015	0.044	NS	0.004
	F1 + 2	0.019	0.287	0.102	- 0.140
	F1 + 2	NS	0.041	NS	NS
	TFPI	0.179	0.325	0.325	- 0.402
	TFPI	NS	0.020	0.020	0.003
Fibrinolysis	PAP	0.046	0.006	0.304	−0.027
	PAP	NS	NS	0.030	NS
	uPA	0.179	0.287	0.247	- 0.329
	uPA	NS	0.040	NS	0.018
	suPAR	0.314	0.427	0.562	- 0.529
	suPAR	0.024	0.002	<0.0001	<0.0001
	tPA	−0.181	- 0.183	0.114	0.121
	tPA	NS	NS	NS	NS
	PAI-1	−0.297	0.004	0.096	0.281
	PAI-1	0.034	NS	NS	0.046
Endothelial function	vWF	0.076	0.165	0.330	- 0.172
	vWF	NS	NS	0.018	NS
	TM	0.393	0.451	0.300	- 0.707
	TM	0.004	0.0008	0.033	<0.0001
	sICAM-1	0.158	0.367	0.496	- 0.232
	sICAM-1	NS	0.008	0.0002	NS
	sVCAM-1	0.527	0.448	0.467	- 0.569
	sVCAM-1	<0.0001	0.0007	0.0006	<0.0001

Results are shown as Spearman’s rank correlation coefficients (R) and its statistical significance (P values)
Abbreviations: TF tissue factor, F1 + 2 prothrombin fragments 1 + 2, TFPI tissue factor pathway inhibitor, PAP plasmin-α2-antiplasmin, uPA urinary plasminogen activator, suPAR soluble urokinase-type plasminogen activator receptor, tPA tissue plasminogen activator, PAI-1 plasminogen activator inhibitor-1, vWF von Willebrand Factor, TM thrombomodulin, sICAM-1 soluble intercellular adhesion molecule-1, sVCAM-1 soluble vascular cell adhesion molecule-1, Cu/Zn SOD Cu/Zn superoxide dismutase 1, hs-CRP high sensitivity C-reactive protein, eGFR estimated glomerular filtration rate, NS non-significant

ISSN: 1471-2369