Table 1 Comparison of variables in critically ill patients with and without Acute Kidney Injury
AKI | No AKI | p value | |
|---|---|---|---|
N = 141 (41.6%) | N = 196 (56%) | ||
Age | 56 ± 19 | 47 ± 20.5 | <0.001 |
Male | 76 (51%) | 91 (48%) | 0.57 |
APACHE II | 25 ± 12 | 21 ± 13.5 | 0.006 |
SAPS II | 42 ± 20 | 30 ± 16 | <0.001 |
Post-operative | 40 (27%) | 68 (35.6%) | 0.09 |
CHF | 16 (11%) | 7 (4%) | 0.009 |
Diabetes | 52 (35%) | 58 (30%) | 0.54 |
COPD | 5 | 6 | 0.93 |
Malignancy | 65 | 84 | 0.86 |
Cirrhosis | 39 | 42 | 0.44 |
Renal Impairment prior to ICU admission | 15 | 18 | 0.91 |
Connective Tissue Disease | 36 | 45 | 0.85 |
Cause of ICU Admission | 0.31 | ||
Severe Sepsis/Septic Shock | 55 | 73 | |
Postoperative Complications | 24 | 36 | |
Respiratory Failure | 20 | 36 | |
Acute Neurologic event | 12 | 19 | |
Heart Failure/Arrhythmia | 17 | 11 | |
Othersa | 15 | 21 | |
Vancomycin | 106 (72%) | 117 (61%) | 0.046 |
Colistin | 48 (32%) | 49 (26%) | 0.10 |
Aminoglycosides | 22 (15%) | 35 (18%) | 0.29 |
Serum Creatinine (mmol/L) | |||
at admission | 145 ± 116 | 86.5 ± 168 | <0.001 |
Day 1 | 153.6 ± 117 | 75.6 ± 17 | < 0.001 |
Day 2 | 148.4 ± 107 | 73.1 ± 7 | < 0.001 |
Day 3 | 147.3 ± 101 | 69.2 ± 6 | < 0.001 |
Urine output (ml/kg/hour) | |||
Day 1 | 0.62 ± 0.6 | 1.36 ± 0.9 | < 0.001 |
Day 2 | 0.74 ± 0.8 | 1.49 ± 0.7 | < 0.001 |
Day 3 | 0.71 ± 0.8 | 1.43 ± 1 | < 0.001 |
MAP (mmHg) mean (SD) | |||
Day 0 | 66 ± 16 | 71 ± 14 | 0.033 |
Day 1 | 68.6 ± 13.3 | 70.7 ± 11.8 | 0.12 |
Day 2 | 69.2 ± 15.8 | 71.4 ± 15 | 0.20 |
Day 3 | 67 ± 18 | 74 ± 15 | 0.002 |
Patients on Vasopressors | |||
Day 1 | 76 | 62 | <0.001 |
Day 2 | 77 | 65 | 0.001 |
Day 3 | 71 | 58 | 0.001 |
Serum Lactate (mmol/L) | |||
at admission | 2.7 ± 1.9 | 2.0 ± 2.6 | 0.02 |
at 6 h | 1.6 (2) | 1.9 (2) | 0.91 |
ScvO2 | |||
at admission | 68.5 ± 24.8 | 71.5 ± 22.6 | 0.86 |
at 24 h | 67 ± 25.4 | 65.7 ± 25 | 0.66 |
Fluid Balance (ml) median(IQR) | |||
Day 1 | + 1500 (3254) | + 869 (2284) | 0.002 |
Day 2 | + 744 (2292) | + 486 (2250) | 0.017 |
Day 3 | + 518 (1521) | 0 (1604) | 0.043 |
Fluid Volume (ml) median(IQR) | |||
Chloride-Liberal fluids in 1st 24 h | 4880 (3342) | 5500 (4729) | 0.20 |
Chloride-Restrictive solutions 1st 24 h | 3665 (2000) | 2610 (2000) | 0.22 |
Chloride-Liberal fluids by 48 h | 1079 (894) | 970 (838) | 0.33 |
Chloride-Restrictive fluids by 48 h | 1949 (650) | 1983 (763) | 0.32 |
Serum Chloride (mmol/L) | |||
at 24 h | 111 ± 18.7 | 113 ± 17 | 0.69 |
at 48 h | 113 ± 15.5 | 113 ± 15 | 0.17 |
ICU mortality | 19 | 27 | 0.89 |
28 day Survival | 114 | 159 | 0.74 |