Risk factor | Linear model | Latent variable mixture model | |
---|---|---|---|
Subpopulation 1 | Subpopulation 2 | ||
Age (per 10 years) | 0.037 (−0.044, 0.118) | 0.040 (−0.021, 0.101) | 0.042 (0.016, 0.068)** |
BMI (per 5 kg/m2) | 0.040 (0.013, 0.068)** | 0.107 (0.081, 0.132)*** | 0.012 (0.005, 0.019)*** |
History of hypertension | 0.005 (−0.046, 0.056) | 0.080 (0.002, 0.158)* | −0.017 (−0.031, −0.003)* |
History of diabetes | −0.024 (−0.082, 0.035) | −0.123 (−0.177, −0.068)*** | −0.007 (−0.021, 0.008) |
Baseline pulse pressure (per 10 mmHg) | 0.003 (−0.009, 0.015) | −0.019 (−0.035, −0.003)* | 0.004 (7.2e-5, 0.008)* |
Baseline SCr (per mg/dL) | 0.203 (−0.309, 0.715) | 0.054 (−0.217, 0.326) | 0.158 (−0.023, 0.339) |
Baseline SCr:age interaction | −0.001 (−0.008, 0.007) | 0.002 (−0.003, 0.007) | −0.001 (−0.003, 0.002) |
Baseline eGFR (per 30 mL/min/1.73 m2) | 0.081 (−0.012, 0.174) | 0.045 (−0.066, 0.156) | 0.099 (0.051, 0.147)*** |
Baseline hematocrit (per %) | −0.010 (−0.016, −0.005)*** | −0.034 (−0.040, −0.028)*** | −0.003 (−0.005, −0.001)*** |
Cardiopulmonary bypass time (per hour) | 0.006 (−0.018, 0.030) | −0.072 (−0.108, −0.036)*** | 0.012 (2.0e-4, 0.024) ** |
Aortic cross clamp time (per hour) | 0.036 (0.001, 0.072)* | 0.156 (0.120, 0.192)*** | −0.006 (−0.018, 0.006) |
Intraoperative hydroxyethyl starch volume (per L) | 0.200 (0.000, 0.400) | 0.300 (0.100, 0.500)** | 0.000 (−0.056, 0.094) |
Intraoperative urine output (per L) | −0.100 (−0.200, −0.048)** | −0.300 (−0.400, −0.200)*** | −0.100 (−0.094, −0.016)*** |
Mean intraoperative MAP adjusted for baseline MAP (per 10 mmHg) | 0.023 (0.003, 0.042)* | 0.064 (0.042, 0.086)*** | 0.005 (0.001, 0.009)* |
Maximum intraoperative lactate (per mmol/L) | 0.004 (−0.021, 0.028) | −0.009 (−0.033, 0.016) | 0.013 (0.007, 0.019)*** |
Length of surgery (per hour) | 0.034 (0.009, 0.059)** | 0.113 (0.086, 0.140)*** | 0.027 (0.021, 0.034)*** |