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Table 2 Number and incidence rate of CVD, all-cause mortality and composite of CVD and all-cause mortality among estimated glomerular filtration rate (eGFR) groups by multivariable Cox proportional hazard regression

From: Association of estimated glomerular filtration rate and urine albumin-to-creatinine ratio with incidence of cardiovascular diseases and mortality in chinese patients with type 2 diabetes mellitus – a population-based retrospective cohort study

  eGFR Group 1
(≥90 ml/min/1.73 m2)
(N = 100,785)
eGFR Group 2
(60–89 ml/min/1.73 m2)
(N = 38,537)
eGFR Group 3
(30–59 ml/min/1.73 m2)
(N = 7,067)
eGFR Group 4
(15–29 ml/min/1.73 m2)
(N = 431)
eGFR Group 5
(<15 ml/min/1.73 m2)
(N = 133)
CVD
 Cumulative Cases with Event 5,552 4,426 1,404 134 38
 Cumulative Incidence Rate 5.5% 11.5% 19.9% 31.1% 28.6%
 Person-years 4,925,567 1,823,869 301,183 12,069 2,871
 Medium follow-up (Months) 51.5 50.5 47.5 24.5 14.5
 Incidence Rate (95% CI) a 13.53 (13.18,13.89) 29.12 (28.28,29.99) 55.94 (53.09,58.94) 133.24 (112.49,157.82) 158.86 (115.59,218.32)
 Hazard Ratio (95% CI) Reference group 1.17* (1.12,1.22) 1.63* (1.52,1.73) 3.17* (2.66,3.78) 4.55* (3.29,6.31)
All-cause mortality
 Cumulative Cases with Event 4,416 3,512 1,546 252 90
 Cumulative Incidence Rate 4.4% 9.1% 21.9% 58.5% 67.7%
 Person-years 5,041,933 1,910,744 325,858 13,944 3,166
 Medium follow-up (Months) 51.5 51.5 49.5 35.5 16.5
 Incidence Rate (95% CI)a 10.51 (10.20,10.82) 22.06 (21.34,22.80) 56.93 (54.16,59.84) 216.88 (191.69,245.38) 341.18 (277.50,419.47)
 Hazard Ratio (95% CI) Reference group 0.99 (0.95,1.04) 1.70* (1.59,1.81) 5.19* (4.55,5.93) 9.49* (7.68,11.73)
Composite of CVD and mortality
 Cumulative Cases with Event 9,062 6,817 2,374 287 96
 Cumulative Incidence Rate 9.0% 17.7% 33.6% 66.6% 72.2%
 Person-years 4,925,567 1,823,869 301,183 12,069 2,871
 Medium follow-up (Months) 51.5 50.5 47.5 24.5 14.5
 Incidence Rate (95% CI)a 22.08 (21.63,22.54) 44.85 (43.80,45.93) 94.59 (90.86,98.47) 285.37 (254.19,320.37) 401.32 (328.56,490.20)
 Hazard Ratio (95% CI) Reference group 1.03 (1.00,1.07) 1.51* (1.44,1.58) 4.09* (3.63,4.62) 7.08* (5.78,8.68)
  1. Hazard ratios were adjusted for age, gender, smoking status, drinking habit, body mass index, waist-to-hip ratio, glycated hemoglobin A1c, systolic and diastolic blood pressure, low-density lipoprotein-cholesterol, total cholesterol to high-density lipoprotein cholesterol ratio, triglyceride, urine albumin/creatinine ratio, self-reported duration of diabetes mellitus, family history of diabetes mellitus, diagnosed hypertension, the usage of anti-hypertensive drugs, oral anti-diabetic drugs, insulin and lipid-lowering agents at baseline
  2. CVD Cardiovascular Diseases, eGFR estimated Glomerular Filtration Rate
  3. *Significant difference (P < 0.05) by multivariable Cox proportional hazards regression
  4. aIncidence rate (cases/1000 person-years) with 95%CI based on Poisson distribution