Skip to main content

Table 2 Number and incidence rate of CVD, all-cause mortality and composite of CVD and all-cause mortality among estimated glomerular filtration rate (eGFR) groups by multivariable Cox proportional hazard regression

From: Association of estimated glomerular filtration rate and urine albumin-to-creatinine ratio with incidence of cardiovascular diseases and mortality in chinese patients with type 2 diabetes mellitus – a population-based retrospective cohort study

 

eGFR Group 1

(≥90 ml/min/1.73 m2)

(N = 100,785)

eGFR Group 2

(60–89 ml/min/1.73 m2)

(N = 38,537)

eGFR Group 3

(30–59 ml/min/1.73 m2)

(N = 7,067)

eGFR Group 4

(15–29 ml/min/1.73 m2)

(N = 431)

eGFR Group 5

(<15 ml/min/1.73 m2)

(N = 133)

CVD

 Cumulative Cases with Event

5,552

4,426

1,404

134

38

 Cumulative Incidence Rate

5.5%

11.5%

19.9%

31.1%

28.6%

 Person-years

4,925,567

1,823,869

301,183

12,069

2,871

 Medium follow-up (Months)

51.5

50.5

47.5

24.5

14.5

 Incidence Rate (95% CI) a

13.53 (13.18,13.89)

29.12 (28.28,29.99)

55.94 (53.09,58.94)

133.24 (112.49,157.82)

158.86 (115.59,218.32)

 Hazard Ratio (95% CI)

Reference group

1.17* (1.12,1.22)

1.63* (1.52,1.73)

3.17* (2.66,3.78)

4.55* (3.29,6.31)

All-cause mortality

 Cumulative Cases with Event

4,416

3,512

1,546

252

90

 Cumulative Incidence Rate

4.4%

9.1%

21.9%

58.5%

67.7%

 Person-years

5,041,933

1,910,744

325,858

13,944

3,166

 Medium follow-up (Months)

51.5

51.5

49.5

35.5

16.5

 Incidence Rate (95% CI)a

10.51 (10.20,10.82)

22.06 (21.34,22.80)

56.93 (54.16,59.84)

216.88 (191.69,245.38)

341.18 (277.50,419.47)

 Hazard Ratio (95% CI)

Reference group

0.99 (0.95,1.04)

1.70* (1.59,1.81)

5.19* (4.55,5.93)

9.49* (7.68,11.73)

Composite of CVD and mortality

 Cumulative Cases with Event

9,062

6,817

2,374

287

96

 Cumulative Incidence Rate

9.0%

17.7%

33.6%

66.6%

72.2%

 Person-years

4,925,567

1,823,869

301,183

12,069

2,871

 Medium follow-up (Months)

51.5

50.5

47.5

24.5

14.5

 Incidence Rate (95% CI)a

22.08 (21.63,22.54)

44.85 (43.80,45.93)

94.59 (90.86,98.47)

285.37 (254.19,320.37)

401.32 (328.56,490.20)

 Hazard Ratio (95% CI)

Reference group

1.03 (1.00,1.07)

1.51* (1.44,1.58)

4.09* (3.63,4.62)

7.08* (5.78,8.68)

  1. Hazard ratios were adjusted for age, gender, smoking status, drinking habit, body mass index, waist-to-hip ratio, glycated hemoglobin A1c, systolic and diastolic blood pressure, low-density lipoprotein-cholesterol, total cholesterol to high-density lipoprotein cholesterol ratio, triglyceride, urine albumin/creatinine ratio, self-reported duration of diabetes mellitus, family history of diabetes mellitus, diagnosed hypertension, the usage of anti-hypertensive drugs, oral anti-diabetic drugs, insulin and lipid-lowering agents at baseline
  2. CVD Cardiovascular Diseases, eGFR estimated Glomerular Filtration Rate
  3. *Significant difference (P < 0.05) by multivariable Cox proportional hazards regression
  4. aIncidence rate (cases/1000 person-years) with 95%CI based on Poisson distribution
Back to article page

BMC Nephrology

ISSN: 1471-2369

Contact us