Skip to main content

Table 3 Number and incidence rate of CVD, all-cause mortality and composite of CVD and all-cause mortality among urine albumin/creatinine ratio (UACR) groups (male) by multivariable Cox proportional hazard regression

From: Association of estimated glomerular filtration rate and urine albumin-to-creatinine ratio with incidence of cardiovascular diseases and mortality in chinese patients with type 2 diabetes mellitus – a population-based retrospective cohort study

  UACR Group 1 (<0.5 mg/mmol)
(N = 5,821)
UACR Group 2
(0.5–0.9 mg/mmol)
(N = 8,796)
UACR Group 3
(1–1.4 mg/mmol)
(N = 3,846)
UACR Group 4
(1.5–1.9 mg/mmol)
(N = 2,183)
UACR Group 5
(2–2.4
mg/mmol)
(N = 1,474)
UACR Group 6
(2.5–3.4 mg/mmol)
(N = 1,906)
UACR Group 7
(3.5–4.9 mg/mmol)
(N = 1,563)
UACR Group 8
(5–9.9 mg/mmol)
(N = 2,308)
UACR Group 9
(10–24.9 mg/mmol)
(N = 1,765)
UACR Group 10
(25–34.9 mg/mmol)
(N = 406)
UACR Group 11 (≥35 mg/mmol)
(N = 1,021)
CVD
 Cumulative Cases with Event 242 417 245 167 112 159 123 248 206 50 154
 Cumulative Incidence Rate 4.2% 4.7% 6.4% 7.7% 7.6% 8.3% 7.9% 10.7% 11.7% 12.3% 15.1%
 Person-years 268,568 399,457 172,506 95,953 65,849 84,092 67,881 99,719 74,531 16,277 39,981
 Medium follow-up (Months) 46.5 45.5 44.5 44.5 45.5 44.5 43.5 43.5 43.5 41.5 41.5
 Incidence Rate (95% CI)a 10.81 (9.53,12.26) 12.53 (11.38,13.79) 17.04 (15.04,19.32) 20.89 (17.95,24.31) 20.41 (16.96,24.56) 22.69 (19.42,26.51) 21.74 (18.22,25.95) 29.84 (26.35,33.80) 33.17 (28.93,38.02) 36.86 (27.94,48.64) 46.22 (39.47,54.13)
 Hazard Ratio (95% CI) Reference group 1.07 (0.91,1.26) 1.30* (1.09,1.56) 1.57* (1.28,1.91) 1.42* (1.13,1.78) 1.58* (1.29,1.94) 1.48* (1.19,1.84) 1.94* (1.62,2.33) 2.00* (1.65,2.42) 2.21* (1.63,3.01) 2.57* (2.08,3.17)
All-cause mortality
 Cumulative Cases with Event 138 277 156 126 79 112 115 165 155 45 160
 Cumulative Incidence Rate 2.4% 3.1% 4.1% 5.8% 5.4% 5.9% 7.4% 7.1% 8.8% 11.1% 15.7%
 Person-years 273,362 407,234 176,630 99,035 68,040 86,781 70,042 103,939 78,012 17,049 42,556
 Medium follow-up (Months) 46.5 45.5 45.5 45.5 45.5 44.5 44.5 44.5 44.5 42.5 42.5
 Incidence Rate (95% CI)a 6.06 (5.13,7.16) 8.16
(7.26,9.18)
10.60 (9.06,12.40) 15.27 (12.82,18.18) 13.93 (11.18,17.37) 15.49 (12.87,18.64) 19.70 (16.41,23.65) 19.05 (16.35,22.19) 23.84 (20.37,27.91) 31.67 (23.65,42.42) 45.12 (38.64,52.68)
 Hazard Ratio (95% CI) Reference group 1.23* (1.00,1.51) 1.41* (1.12,1.77) 1.93* (1.51,2.46) 1.53* (1.16,2.02) 1.79* (1.39,2.31) 2.29* (1.78,2.94) 2.08* (1.65,2.62) 2.41* (1.90,3.05) 3.26* (2.32,4.59) 4.36* (3.43,5.53)
Composite of CVD and mortality
 Cumulative Cases with Event 361 648 359 264 165 239 217 353 315 77 265
 Cumulative Incidence Rate 6.2% 7.4% 9.3% 12.1% 11.2% 12.5% 13.9% 15.3% 17.8% 19.0% 26.0%
 Person-years 268,568 399,457 172,506 95,953 65,849 84,092 67,881 99,719 74,531 16,277 39,981
 Medium follow-up (Months) 46.5 45.5 44.5 44.5 45.5 44.5 43.5 43.5 43.5 41.5 41.5
 Incidence Rate (95% CI)a 16.13 (14.55,17.88) 19.47 (18.02,21.02) 24.97 (22.52,27.69) 33.02 (29.26,37.25) 30.07 (25.81,35.03) 34.11 (30.04,38.72) 38.36 (33.58,43.82) 42.48 (38.27,47.15) 50.72 (45.41,56.64) 56.77 (45.40,70.97) 79.54 (70.52,89.72)
 Hazard Ratio (95% CI) Reference group 1.14 (1.00,1.29) 1.32* (1.14,1.53) 1.70* (1.45,1.99) 1.37* (1.14,1.65) 1.59* (1.34,1.87) 1.85* (1.56,2.19) 1.88* (1.62,2.18) 2.16* (1.85,2.52) 2.64* (2.06,3.39) 3.41* (2.89,4.03)
  1. Hazard ratios were adjusted for age, gender, smoking status, drinking habit, body mass index, waist-to-hip ratio, glycated hemoglobin A1c, systolic and diastolic blood pressure, low-density lipoprotein-cholesterol, total cholesterol to high-density lipoprotein cholesterol ratio, triglyceride, estimated Glomerular Filtration Rate, self-reported duration of diabetes mellitus, family history of diabetes mellitus, diagnosed hypertension, the usage of anti-hypertensive drugs, oral anti-diabetic drugs, insulin and lipid-lowering agents at baseline
  2. CVD Cardiovascular Diseases, UACR Albumin/Creatinine Ratio
  3. *Significant difference (P < 0.05) by multivariable Cox proportional hazards regression
  4. aIncidence rate (cases/1000 person-years) with 95%CI based on Poisson distribution