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Table 4 Number and incidence rate of CVD, all-cause mortality and composite of CVD and all-cause mortality among urine albumin/creatinine ratio (UACR) groups (female) by multivariable Cox proportional hazard regression

From: Association of estimated glomerular filtration rate and urine albumin-to-creatinine ratio with incidence of cardiovascular diseases and mortality in chinese patients with type 2 diabetes mellitus – a population-based retrospective cohort study

  UACR Group 1 (<0.5 mg/mmol)
(N = 3,277)
UACR Group 2
(0.5–0.9 mg/mmol)
(N = 9,836)
UACR Group 3
(1–1.4 mg/mmol)
(N = 5,714)
UACR Group 4
(1.5–1.9 mg/mmol)
(N = 3,245)
UACR Group 5
(2–2.4 mg/mmol)
(N = 2,210)
UACR Group 6
(2.5–3.4
mg/mmol)
(N = 2,694)
UACR Group 7
(3.5–4.9 mg/mmol)
(N = 2,155)
UACR Group 8
(5–9.9 mg/mmol)
(N = 2,965)
UACR Group 9
(10–24.9 mg/mmol)
(N = 2,306)
UACR Group 10
(25–34.9 mg/mmol)
(N = 502)
UACR Group 11 (≥35 mg/mmol)
(N = 1,341)
CVD
 Cumulative Cases with Event 115 414 295 195 128 195 161 257 268 59 215
 Cumulative Incidence Rate 3.5% 4.2% 5.2% 6.0% 5.8% 7.2% 7.5% 8.7% 11.6% 11.8% 16.0%
 Person-years 154,111 455,441 260,056 148,173 100,254 120,471 95,349 130,004 100,133 21,349 54,205
 Medium follow-up (Months) 47.5 46.5 45.5 45.5 45.5 44.5 44.5 44.5 44.5 43.5 41.5
 Incidence Rate (95% CI)a 8.95 (7.46,10.75) 10.91 (9.91,12.01) 13.61 (12.14,15.26) 15.79 (13.72,18.17) 15.32 (12.88,18.22) 19.42 (16.88,22.35) 20.26 (17.36,23.65) 23.72 (20.99,26.81) 32.12 (28.49,36.20) 33.16 (25.69,42.80) 47.60 (41.64,54.40)
 Hazard Ratio (95% CI) Reference group 1.14 (0.93,1.40) 1.20 (0.97,1.49) 1.34* (1.06,1.69) 1.21 (0.94,1.56) 1.51* (1.20,1.90) 1.48* (1.17,1.89) 1.58* (1.27,1.98) 2.00* (1.60,2.49) 1.84* (1.34,2.53) 2.40* (1.90,3.03)
All-cause mortality
 Cumulative Cases with Event 52 184 151 102 83 114 113 163 146 47 151
 Cumulative Incidence Rate 1.6% 1.9% 2.6% 3.1% 3.8% 4.2% 5.2% 5.5% 6.3% 9.4% 11.3%
 Person-years 156,248 463,725 265,206 151,359 102,518 123,314 98,097 134,594 104,628 22,326 57,656
 Medium follow-up (Months) 48.5 46.5 45.5 46.5 45.5 45.5 45.5 45.5 45.5 44.5 43.5
 Incidence Rate (95% CI)a 3.99 (3.04,5.24) 4.76 (4.12,5.50) 6.83 (5.83,8.01) 8.09 (6.66,9.82) 9.72 (7.83,12.05) 11.09 (9.23,13.33) 13.82 (11.50,16.62) 14.53 (12.46,16.94) 16.75 (14.24,19.69) 25.26 (18.98,33.62) 31.43 (26.79,36.86)
 Hazard Ratio (95% CI) Reference group 1.08 (0.80,1.48) 1.27 (0.92,1.74) 1.43* (1.02,1.99) 1.60* (1.13,2.26) 1.77* (1.27,2.47) 2.08* (1.49,2.90) 1.97* (1.43,2.70) 2.07* (1.50,2.85) 2.60* (1.74,3.88) 3.07* (2.22,4.25)
Composite of CVD and mortality
 Cumulative Cases with Event 159 560 395 265 193 271 237 374 340 88 296
 Cumulative Incidence Rate 4.9% 5.7% 6.9% 8.2% 8.7% 10.1% 11.0% 12.6% 14.7% 17.5% 22.1%
 Person-years 154,111 455,441 260,056 148,173 100,254 120,471 95,349 130,004 100,133 21,349 54,205
 Medium follow-up (Months) 47.5 46.5 45.5 45.5 45.5 44.5 44.5 44.5 44.5 43.5 41.5
 Incidence Rate (95% CI)a 12.38 (10.60,14.46) 14.75 (13.58,16.03) 18.23 (16.52,20.12) 21.46 (19.03,24.21) 23.10 (20.06,26.60) 26.99 (23.96,30.41) 29.83 (26.26,33.88) 34.52 (31.19,38.20) 40.75 (36.64,45.32) 49.46 (40.14,60.96) 65.53 (58.47,73.44)
 Hazard Ratio (95% CI) Reference group 1.12 (0.94,1.33) 1.17 (0.97,1.41) 1.31* (1.08,1.60) 1.34* (1.09,1.66) 1.58* (1.29,1.92) 1.57* (1.28,1.93) 1.73* (1.43,2.08) 1.89* (1.56,2.29) 2.00* (1.54,2.60) 2.54* (2.08,3.09)
  1. Hazard ratios were adjusted for age, gender, smoking status, drinking habit, body mass index, waist-to-hip ratio, glycated hemoglobin A1c, systolic and diastolic blood pressure, low-density lipoprotein-cholesterol, total cholesterol to high-density lipoprotein cholesterol ratio, triglyceride, estimated Glomerular Filtration Rate, self-reported duration of diabetes mellitus, family history of diabetes mellitus, diagnosed hypertension, the usage of anti-hypertensive drugs, oral anti-diabetic drugs, insulin and lipid-lowering agents at baseline
  2. CVD Cardiovascular Diseases, UACR Urine Albumin/Creatinine Ratio
  3. *Significant difference (P < 0.05) by multivariable Cox proportional hazards regression
  4. aIncidence rate (cases/1000 person-years) with 95%CI based on Poisson distribution