Table 4 Number and incidence rate of CVD, all-cause mortality and composite of CVD and all-cause mortality among urine albumin/creatinine ratio (UACR) groups (female) by multivariable Cox proportional hazard regression
UACR Group 1 (<0.5 mg/mmol) (N = 3,277) | UACR Group 2 (0.5–0.9 mg/mmol) (N = 9,836) | UACR Group 3 (1–1.4 mg/mmol) (N = 5,714) | UACR Group 4 (1.5–1.9 mg/mmol) (N = 3,245) | UACR Group 5 (2–2.4 mg/mmol) (N = 2,210) | UACR Group 6 (2.5–3.4 mg/mmol) (N = 2,694) | UACR Group 7 (3.5–4.9 mg/mmol) (N = 2,155) | UACR Group 8 (5–9.9 mg/mmol) (N = 2,965) | UACR Group 9 (10–24.9 mg/mmol) (N = 2,306) | UACR Group 10 (25–34.9 mg/mmol) (N = 502) | UACR Group 11 (≥35 mg/mmol) (N = 1,341) | |
|---|---|---|---|---|---|---|---|---|---|---|---|
CVD | |||||||||||
Cumulative Cases with Event | 115 | 414 | 295 | 195 | 128 | 195 | 161 | 257 | 268 | 59 | 215 |
Cumulative Incidence Rate | 3.5% | 4.2% | 5.2% | 6.0% | 5.8% | 7.2% | 7.5% | 8.7% | 11.6% | 11.8% | 16.0% |
Person-years | 154,111 | 455,441 | 260,056 | 148,173 | 100,254 | 120,471 | 95,349 | 130,004 | 100,133 | 21,349 | 54,205 |
Medium follow-up (Months) | 47.5 | 46.5 | 45.5 | 45.5 | 45.5 | 44.5 | 44.5 | 44.5 | 44.5 | 43.5 | 41.5 |
Incidence Rate (95% CI)a | 8.95 (7.46,10.75) | 10.91 (9.91,12.01) | 13.61 (12.14,15.26) | 15.79 (13.72,18.17) | 15.32 (12.88,18.22) | 19.42 (16.88,22.35) | 20.26 (17.36,23.65) | 23.72 (20.99,26.81) | 32.12 (28.49,36.20) | 33.16 (25.69,42.80) | 47.60 (41.64,54.40) |
Hazard Ratio (95% CI) | Reference group | 1.14 (0.93,1.40) | 1.20 (0.97,1.49) | 1.34* (1.06,1.69) | 1.21 (0.94,1.56) | 1.51* (1.20,1.90) | 1.48* (1.17,1.89) | 1.58* (1.27,1.98) | 2.00* (1.60,2.49) | 1.84* (1.34,2.53) | 2.40* (1.90,3.03) |
All-cause mortality | |||||||||||
Cumulative Cases with Event | 52 | 184 | 151 | 102 | 83 | 114 | 113 | 163 | 146 | 47 | 151 |
Cumulative Incidence Rate | 1.6% | 1.9% | 2.6% | 3.1% | 3.8% | 4.2% | 5.2% | 5.5% | 6.3% | 9.4% | 11.3% |
Person-years | 156,248 | 463,725 | 265,206 | 151,359 | 102,518 | 123,314 | 98,097 | 134,594 | 104,628 | 22,326 | 57,656 |
Medium follow-up (Months) | 48.5 | 46.5 | 45.5 | 46.5 | 45.5 | 45.5 | 45.5 | 45.5 | 45.5 | 44.5 | 43.5 |
Incidence Rate (95% CI)a | 3.99 (3.04,5.24) | 4.76 (4.12,5.50) | 6.83 (5.83,8.01) | 8.09 (6.66,9.82) | 9.72 (7.83,12.05) | 11.09 (9.23,13.33) | 13.82 (11.50,16.62) | 14.53 (12.46,16.94) | 16.75 (14.24,19.69) | 25.26 (18.98,33.62) | 31.43 (26.79,36.86) |
Hazard Ratio (95% CI) | Reference group | 1.08 (0.80,1.48) | 1.27 (0.92,1.74) | 1.43* (1.02,1.99) | 1.60* (1.13,2.26) | 1.77* (1.27,2.47) | 2.08* (1.49,2.90) | 1.97* (1.43,2.70) | 2.07* (1.50,2.85) | 2.60* (1.74,3.88) | 3.07* (2.22,4.25) |
Composite of CVD and mortality | |||||||||||
Cumulative Cases with Event | 159 | 560 | 395 | 265 | 193 | 271 | 237 | 374 | 340 | 88 | 296 |
Cumulative Incidence Rate | 4.9% | 5.7% | 6.9% | 8.2% | 8.7% | 10.1% | 11.0% | 12.6% | 14.7% | 17.5% | 22.1% |
Person-years | 154,111 | 455,441 | 260,056 | 148,173 | 100,254 | 120,471 | 95,349 | 130,004 | 100,133 | 21,349 | 54,205 |
Medium follow-up (Months) | 47.5 | 46.5 | 45.5 | 45.5 | 45.5 | 44.5 | 44.5 | 44.5 | 44.5 | 43.5 | 41.5 |
Incidence Rate (95% CI)a | 12.38 (10.60,14.46) | 14.75 (13.58,16.03) | 18.23 (16.52,20.12) | 21.46 (19.03,24.21) | 23.10 (20.06,26.60) | 26.99 (23.96,30.41) | 29.83 (26.26,33.88) | 34.52 (31.19,38.20) | 40.75 (36.64,45.32) | 49.46 (40.14,60.96) | 65.53 (58.47,73.44) |
Hazard Ratio (95% CI) | Reference group | 1.12 (0.94,1.33) | 1.17 (0.97,1.41) | 1.31* (1.08,1.60) | 1.34* (1.09,1.66) | 1.58* (1.29,1.92) | 1.57* (1.28,1.93) | 1.73* (1.43,2.08) | 1.89* (1.56,2.29) | 2.00* (1.54,2.60) | 2.54* (2.08,3.09) |