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Table 2 Mean change from baseline in kidney function and Calcium/Phosphorus and the results of the test of the fixed effects by the linear mixed effect model analyses

From: Risedronate therapy in patients with mild-to-moderate chronic kidney disease with osteoporosis: post-hoc analysis of data from the risedronate phase III clinical trials

 

eGFR (mL/min/1.73 m2)

90

60 to < 90

30 to < 60

N

Mean

SD

N

Mean

SD

N

Mean

SD

eGFR (mL/min/1.73 m2)

Baseline

99

99.19

9.56

525

72.12

7.98

228

50.74

6.54

12 weeks

94

91.84

15.90

498

70.77

10.92

209

54.43

10.43

24 weeks

89

88.89

12.24

482

70.74

11.26

201

54.64

10.41

36 weeks

86

91.22

13.91

455

71.75

11.65

184

55.54

10.59

48 weeks

84

93.04

14.08

441

72.11

11.95

177

55.06

11.48

 

subgroup

P < 0.0001

time

P < 0.0001

interaction of the subgroup and time

P < 0.0001

Creatinine (mg/dL)

Baseline

99

0.48

0.05

525

0.64

0.07

228

0.86

0.12

12 weeks

94

0.53

0.09

498

0.65

0.10

209

0.82

0.16

24 weeks

89

0.54

0.08

482

0.65

0.10

201

0.82

0.16

36 weeks

86

0.53

0.09

455

0.65

0.10

184

0.81

0.15

48 weeks

84

0.52

0.08

441

0.64

0.11

177

0.82

0.17

 

subgroup

P < 0.0001

time

P = 0.0178

interaction of the subgroup and time

P < 0.0001

Calcium (mg/dL)

Baseline

99

9.15

0.37

525

9.08

0.41

228

9.05

0.40

12 weeks

83

9.10

0.39

387

9.10

0.38

115

9.07

0.41

24 weeks

88

9.13

0.36

481

9.12

0.41

198

9.07

0.40

36 weeks

79

9.11

0.40

356

9.17

0.41

111

9.21

0.37

48 weeks

83

9.14

0.35

441

9.13

0.41

182

9.09

0.44

 

subgroup

P = 0.4597

time

P < 0.0001

interaction of the subgroup and time

P = 0.1129

Phosphorus (mg/dL)

Baseline

26

3.52

0.34

187

3.36

0.47

146

3.43

0.52

12 weeks

14

3.48

0.43

59

3.29

0.49

36

3.36

0.45

24 weeks

22

3.28

0.46

162

3.22

0.55

119

3.31

0.48

36 weeks

14

3.14

0.36

51

3.14

0.48

34

3.31

0.60

48 weeks

20

3.44

0.45

146

3.32

0.48

109

3.35

0.51

 

subgroup

P = 0.0888

time

P < 0.0001

interaction of the subgroup and time

P = 0.1041

  1. The linear mixed models included subgroup, time, and interaction of subgroup and time as fixed effects, and the subjects as a random effect