| |
eGFR (mL/min/1.73 m2)
|
|---|
| ≧90 | ≧60 to < 90 | ≧30 to < 60 |
|---|
|
N
|
Mean
|
SD
|
N
|
Mean
|
SD
|
N
|
Mean
|
SD
|
|---|
|
eGFR (mL/min/1.73 m2)
|
Baseline
|
99
|
99.19
|
9.56
|
525
|
72.12
|
7.98
|
228
|
50.74
|
6.54
|
|
12 weeks
|
94
|
91.84
|
15.90
|
498
|
70.77
|
10.92
|
209
|
54.43
|
10.43
|
|
24 weeks
|
89
|
88.89
|
12.24
|
482
|
70.74
|
11.26
|
201
|
54.64
|
10.41
|
|
36 weeks
|
86
|
91.22
|
13.91
|
455
|
71.75
|
11.65
|
184
|
55.54
|
10.59
|
|
48 weeks
|
84
|
93.04
|
14.08
|
441
|
72.11
|
11.95
|
177
|
55.06
|
11.48
|
| |
subgroup
|
P < 0.0001
|
|
time
|
P < 0.0001
|
|
interaction of the subgroup and time
|
P < 0.0001
|
|
Creatinine (mg/dL)
|
Baseline
|
99
|
0.48
|
0.05
|
525
|
0.64
|
0.07
|
228
|
0.86
|
0.12
|
|
12 weeks
|
94
|
0.53
|
0.09
|
498
|
0.65
|
0.10
|
209
|
0.82
|
0.16
|
|
24 weeks
|
89
|
0.54
|
0.08
|
482
|
0.65
|
0.10
|
201
|
0.82
|
0.16
|
|
36 weeks
|
86
|
0.53
|
0.09
|
455
|
0.65
|
0.10
|
184
|
0.81
|
0.15
|
|
48 weeks
|
84
|
0.52
|
0.08
|
441
|
0.64
|
0.11
|
177
|
0.82
|
0.17
|
| |
subgroup
|
P < 0.0001
|
|
time
|
P = 0.0178
|
|
interaction of the subgroup and time
|
P < 0.0001
|
|
Calcium (mg/dL)
|
Baseline
|
99
|
9.15
|
0.37
|
525
|
9.08
|
0.41
|
228
|
9.05
|
0.40
|
|
12 weeks
|
83
|
9.10
|
0.39
|
387
|
9.10
|
0.38
|
115
|
9.07
|
0.41
|
|
24 weeks
|
88
|
9.13
|
0.36
|
481
|
9.12
|
0.41
|
198
|
9.07
|
0.40
|
|
36 weeks
|
79
|
9.11
|
0.40
|
356
|
9.17
|
0.41
|
111
|
9.21
|
0.37
|
|
48 weeks
|
83
|
9.14
|
0.35
|
441
|
9.13
|
0.41
|
182
|
9.09
|
0.44
|
| |
subgroup
|
P = 0.4597
|
|
time
|
P < 0.0001
|
|
interaction of the subgroup and time
|
P = 0.1129
|
|
Phosphorus (mg/dL)
|
Baseline
|
26
|
3.52
|
0.34
|
187
|
3.36
|
0.47
|
146
|
3.43
|
0.52
|
|
12 weeks
|
14
|
3.48
|
0.43
|
59
|
3.29
|
0.49
|
36
|
3.36
|
0.45
|
|
24 weeks
|
22
|
3.28
|
0.46
|
162
|
3.22
|
0.55
|
119
|
3.31
|
0.48
|
|
36 weeks
|
14
|
3.14
|
0.36
|
51
|
3.14
|
0.48
|
34
|
3.31
|
0.60
|
|
48 weeks
|
20
|
3.44
|
0.45
|
146
|
3.32
|
0.48
|
109
|
3.35
|
0.51
|
| |
subgroup
|
P = 0.0888
|
|
time
|
P < 0.0001
|
|
interaction of the subgroup and time
|
P = 0.1041
|
- The linear mixed models included subgroup, time, and interaction of subgroup and time as fixed effects, and the subjects as a random effect
