Table 2 Grade of evidence for primary outcomes
Early RRT compared to Late RRT for aki | |||||
|---|---|---|---|---|---|
Outcomes | No of participants (studies) | Quality of evidence (GRADE) | Relative effect (95% CI) | Anticipated absolute effects | |
Follow up | Risk with Late RRT | Risk difference with Early RRT (95% CI) | |||
Overall mortality | 1672 (10 studies) | ⊕⊝ ⊕ ⊝ Lowa,b due to risk of bias, inconsistency | RR 0.93 (0.75 to 1.15) | study population | |
414 per 1000 | 29 fewer per 1000 (from 104 fewer to 62 more) | ||||
Day 30 mortality | 1301 (6 studies) | ⊕⊝ ⊕ ⊝ Lowa,b due to risk of bias, inconsistency | RR 0.85 (0.6 to 1.2) | study population | |
430 per 1000 | 65 fewer per 1000 (from 172 fewer to 86 more) | ||||
Day 60 mortality | 1075 (3 studies) | ⊕⊝ ⊕ ⊝ Lowa,b due to risk of bias, inconsistency | RR (0.64 to 1.27) | study population | |
473 per 1000 | 47 fewer per 1000 (from 170 fewer to 128 more) | ||||
Day 90 mortality | 555 (3 studies) | ⊕⊝ ⊕ ⊝ Lowa,b due to risk of bias, inconsistency | RR (0.49 to 1.64) | study population | |
449 per 1000 | 45 fewer per 1000 (from 229 fewer to 287 more) | ||||
Overall ICU mortality | 430 (3 studies) | ⊕⊝ ⊕ ⊝ Lowa,b due to risk of bias, inconsistency | RR (0.75 to 1.68) | study population | |
350 per 1000 | 42 fewer per 1000 (from 87 fewer to 238 more) | ||||
Overall Hospital mortality | 713 (6 studies) | ⊕⊝ ⊕ ⊝ Lowa,b due to risk of bias, inconsistency | RR (0.7 to 1.68) | study population | |
298 per 1000 | 24 fewer per 1000 (from 89 fewer to 203 more) | ||||
Dialysis dependence at day 90 | 539 (3 studies) | ⊕⊝ ⊕ ⊝ Lowa,b due to risk of bias, inconsistency | RR (0.51 to 2.22) | study population | |
54 per 1000 | 3 more per 1000 (from 27 fewer to 66 more) | ||||