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Table 2 Characteristics of studies included in stage I

From: Biomarkers for the detection of renal fibrosis and prediction of renal outcomes: a systematic review

Reference Biomarker Age (years)
Mean ± SD
Median (range)
Sex
(% Male)
Race
(% Caucasian)
Method used to obtain GFR Baseline GFR
Mean ± SD
Median (range)
El Ghoul et al [14] Urine PIIINP 46 ± 17 48% 88% Four variable MDRD 48.9 (3.4 - 203.1)
Teppo et al [15] Urine PIIINP 47 (22-68) 61% NR 24-h creatinine clearance 56.2
Soylemezoglu et al [16] Urine and blood PIIINP 51 ± 18 NR NR NR NR
Honkanen et al [20] Urine TGF- β 43a 65% NR 51Cr-EDTA- clearance or 24-h creatinine clearance NR
Susianti et al [21] Urine TGF- β 30b 7% NR NR NR
Murakami et al [22] Urine TGF-β NR NR NR NR NR
Zhang et al [24] Urine MCP-1, Hepcidin, LFABP 30 (17-51) 11% 46% NR NR
Chang et al [25] Blood PAI-1 51a 10% NR MDRD 31.5c
Sanders et al [26] Urine MMP-2
Urine TIMP-1
67 (23-86) NR NR NR NR
Grenzi et al [18] Blood CD30 35 (4.8–67.1) 56% 29% Cockgraft-gault NR
Amer et al [10] Urine RBP 52 ± 13 55% 93% Four variable MDRD
Iothalamate measurement
53.7 ± 14.9
57.5 ± 17.1
Barbosa de Deus
et al [11]
Urine RBP 33 ± 12 54% 53% Creatinine clearance 73.2 (33-172)d
97.5 (45-175)
Pallet et al [12] Urine RBP 53 ± 18 54% 53% MDRD 47.4 ± 33.3
Zhu et al [13] Blood VCAM-1 33 ± 11 47% NR NR 85.4 ± 30.3
Metalidis et al [17] Urine CTGF 53 ± 13.2 61% NR MDRD 53.3 ± 17.4
Liu et al [19] Urine MBL 35 57% NR Four variable MDRD 85.9
Lu et al [23] Urine SGK-1 38b 52% NR MDRD 90.8 ± 43.2
  1. CTGF connective tissue growth factor, GFR glomerular filtration rate, LFABP liver-type fatty acid-binding protein, MBL mannose-binding lectin, MCP-1 monocyte chemoattractant protein-1, MMP-2 matrix metalloproteinase-2, NR not reported, PAI-1 plasminogen activator inhibitor 1, PIIINP amino-terminal propeptide of type III procollagen, RBP retinol- binding protein, SD standard deviation, SGK-1 serum- and glucocorticoid-inducible kinase, TIMP-1 tissue inhibitor of metalloproteinase-1, TGF- β transforming growth factor-beta, VCAM vascular cell adhesion molecule
  2. aThis age was obtained by taking the average of the median ages
  3. bThis age was obtained by taking the average of the mean ages
  4. cThis GFR represents the average of the medians
  5. dThe top GFR represents patients with abnormal RBP and the bottom GFR represents patients with normal RBP