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Table 4 Characteristics of Studies Included in stage II of the review

From: Biomarkers for the detection of renal fibrosis and prediction of renal outcomes: a systematic review

Reference Biomarker Multicenter vs. single center Age (years)
Mean ± SD
Median (range)
Sex (% Male) Race (% Caucasian) Method used to obtain GFR Baseline GFR or serum creatinine
Mean ± SD
Median (range)
Chen et al [29] Urine TGF-β Single centered 64a 62% NR 99mTc-DTPA dynamic renal scintigraphy 6.7 ± 1.7 ml/min/m2 c
11.9 ± 2.4 ml/min/m2 d
Harris et al [30] Blood TGF-β Single centered 43b 60% 85% NA 2.5 mg/dle
2.1 mg/dlf
Wong et al [31] Blood total TGF-β
Blood active TGF-β
Multi-centered (25 international centers) 69 ± 7
69 ± 7 (HC)
70% NR CKD EPI 55.1 ± 19.8 ml/min/m2 70.7 ± 15.8 ml/min/m2 (HC)
Hsu et al [27] Blood MMP-2 Single centered 67a 86% NR CKD-EPI 73.6 ± 15.3 ml/min/m2
Shi et al [28] Urine MMP-2 Single centered 46a
51 ± 10.2 (HC)
31% NR CKD-EPI 34.3 ml/min/m2g
72.2 ± 10.6 ml/min/m2 (HC)
Titan et al [32] Urine MCP-1 Single centered 58 ± 10.2 63% 41% 24-h creatinine clearance 45.2 ± 22.7 ml/min/m2
Verhave et al [33] Urine MCP-1 Multi-centered (4 different hospitals) 69 ± 10 80% 87% 4 variable MDRD 25.0 ± 9.0 ml/min/m2
Ogliari et al [34] Blood MCP-1 Single centered 38 ± 7.2 (r)
28 ± 9 (d)
57% NR NA 7.9 ± 3.4 mg/dl (r)h
0.9 ± 0.3 mg/dl (d)
Nadkarni et al [35] Urine MCP-1 Multi-centered Controls
61.9 ± 5.4
Cases
62.3 ± 5.6
Controls
51%
Cases
52%
Cases and controls
74%
CKD EPI Controls
90.2 ml/min/m2
Cases
87.0 ml/min/m2
  1. CKD-EPI chronic kidney disease epidemiology collaboration, d donor, DTPA diethylenetriaminepentaacetic acid, GFR glomerular filtration rate, HC Healthy controls, MDRD Modification of Diet in Renal Disease, MMP-2 matrix metalloprotinease-2, MCP-1 monocyte chemoattractant protein-1, NR not reported, r recipient, SD Standard deviation, TGF-β Transforming growth factor-beta
  2. aThis age was obtained by taking the average of the mean ages
  3. bThis age represents the average of the mean ages of participants at time of transplant
  4. cPre-operative GFR in obstructed kidney
  5. dPost-operative GFR after percutaneous nephrostomy
  6. eSerum creatinine at transplant
  7. f Serum creatinine 1 month post transplant
  8. gThis GFR represents the average of the means
  9. hRecipients were on dialysis for 4.0 ± 2.4 years