Skip to main content

Table 2 The associations between time-varying blood pressure and GFR change rates in linear mixed regression analyses. The RENIS-FU study

From: Blood pressure and age-related GFR decline in the general population

BP component Model 1a Model 2b
Beta (mL/min/year) 95% confidence interval P-value Beta (mL/min/year) 95% confidence interval P-value
Systolic BP per 10 mmHg 0.09 0.02 to 0.17 0.02 0.10 0.02 to 0.18 0.02
Diastolic BP per 10 mmHg 0.16 0.02 to 0.30 0.03 0.20§ 0.05 to 0.34 0.01
Pulse pressure per 10 mmHg 0.08 -0.03 to 0.19 0.15 0.07 -0.04 to 0.18 0.21
Mean arterial pressure per 10 mmHg 0.15 0.03 to 0.27 0.01 0.17|| 0.05 to 0.30 0.007
  1. Each horizontal section in the table corresponds to one linear mixed regression model. Negative coefficients indicate a steeper GFR decline; positive coefficients a slower decline. The models used time-varying independent variables measured at both baseline and follow-up
  2. Abbreviations: RENIS-FU Study the Renal Iohexol-clearance Survey Follow-up Study, BP blood pressure
  3. aModel 1 adjusted for age; sex; body weight; height; individual dichotomous variables for the use of ACE-inhibitors, A2-receptor blockers, beta-blockers, calcium-blockers, diuretics and other antihypertensives
  4. bAdjusted as model 1 and in addition LDL-cholesterol, HDL-cholesterol, fasting triglycerides, fasting glucose, urinary ACR, pulse frequency, number of cigarettes currently smoked, a dichotomous variable for the weekly use of alcohol or not
  5. P < 0.001 for the interaction between systolic BP and the use of any antihypertensive medication. Beta = 0.01 without and 0.33 mL/min/year/10 mmHg with antihypertensive medication
  6. § P = 0.001 for the interaction between diastolic BP and the use of any antihypertensive medication. Beta = 0.09 without and 0.42 mL/min/year/10 mmHg with antihypertensive medication
  7. || P < 0.001 for the interaction between mean arterial pressure and the use of any antihypertensive medication. Beta = 0.05 without and 0.49 mL/min/year/10 mmHg with antihypertensive medication