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Table 1 Baseline characteristics of patients according to delta neutrophil index

From: Delta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy

Variables

Total (n = 286)

1st tertile

(n = 94, < 3.6%)

2nd tertile

(n = 96, 3.6–12.0%)

3rd tertile

(n = 96, > 12.0%)

P value

Age (year)

61.0 ± 14.7

60.6 ± 15.5

62.2 ± 14.8

60.2 ± 13.8

0.626

Male (%)

180 (63.2)

58 (62.4)

57 (59.4)

65 (67.7)

0.480

MAP (mmHg)

75.9 ± 13.7

78.9 ± 15.7

75.7 ± 12.1

73.3 ± 12.7

0.016

APACHE II score

26.8 ± 7.6

24.6 ± 8.3

28.0 ± 7.2

27.9 ± 7.0

0.003

SOFA score

13.1 ± 3.7

12.1 ± 4.0

13.1 ± 3.8

14.1 ± 3.0

0.001

Charlson comorbidity score

13.1 ± 2.1

13.2 ± 2.2

13.0 ± 2.2

12.9 ± 1.8

0.611

RIFLE criteria (%)a

 Risk

129 (45.1)

42 (44.7)

45 (46.9)

42 (43.8)

0.666

 Injury

82 (28.7)

25 (26.6)

31 (32.3)

26 (27.1)

 

 Failure

75 (26.2)

27 (28.7)

20 (20.8)

28 (29.2)

 

Comorbid diseases (%)

 Hypertension

111 (38.8)

40 (42.6)

43 (44.8)

28 (29.2)

0.056

 Diabetes mellitus

98 (34.3)

42 (44.7)

32 (33.3)

24 (25.0)

0.016

Biochemical data

 DNI (%)

6.10 (2.73–19.78)

1.35 (0–2.71)

6.00 (4.40–8.40)

27.9 (19.18–43.60)

<0.001b

 Hemoglobin (g/dL)

9.6 ± 5.3

9.3 ± 2.2

9.4 ± 2.1

10.3 ± 8.6

0.349

 WBC (103/mm3)

11.6 (5.7–18.1)

13.6 (7.0–17.4)

13.9 (9.5–20.6)

7.5 (3.3–17.5)

0.002b

 Platelet (103/ mm3)

86 (51–163)

112 (62–207)

100 (61–185)

57 (41–94)

<0.001b

 eGFR (mL/min/1.73 m2)

30.9 ± 17.0

27.9 ± 16.0

32.3 ± 17.2

32.5 ± 17.6

0.114

 Cholesterol (mg/dL)

93.2 ± 47.8

104.7 ± 51.4

94.3 ± 44.8

81.4 ± 44.7

0.008

 Albumin (g/dL)

2.7 ± 0.6

2.8 ± 0.6

2.7 ± 0.7

2.6 ± 0.6

0.088

 hs-CRP (mg/L)

104.6 (34.3–199.8)

71.4 (19.7–160.1)

114.5 (44.0–196.8)

128.3 (35.6–279.9)

0.126b

 Total bilirubin (mg/dL)

1.6 (0.7–3.6)

1.6 (0.7–4.7)

1.4 (0.6–3.6)

1.9 (0.7–3.4)

0.523b

 PT (INR)

1.6 ± 0.7

1.6 ± 0.6

1.5 ± 0.6

1.8 ± 0.8

0.003

 aPTT (sec)

48.9 ± 28.0

42.0 ± 16.2

44.1 ± 22.7

59.8 ± 36.9

<0.001

  1. Abbreviations: MAP mean arterial pressure, APACHE Acute Physiology and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment, DM diabetes mellitus, DNI delta neutrophil index, WBC white blood cells, Cr creatinine, eGFR estimated glomerular filtration rate, hs-CRP high sensitivity C-reactive protein, PT prothrombin time, aPTT activated partial thromboplastin time, ICU intensive care unit
  2. aAt ICU hospitalization; At the time of CRRT, 177 (61.9%) patients were classified as RIFLE-I, and the remaining 109 (38.1%) patients were classified as RIFEL-F; bKruskal-Wallis test
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BMC Nephrology

ISSN: 1471-2369

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