Delta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy

Table 2 Baseline characteristics of patients according to the 28-day mortality event

Variables	Survivor (n = 94, 32.9%)	Non-survivor (n = 192, 67.1%)	P value
Age (year)	59.6 ± 14.9	61.7 ± 14.6	0.257
Male (%)	61 (65.6)	119 (62.0)	0.553
MAP (mmHg)	81.7 ± 13.9	73.1 ± 12.8	<0.001
APACHE II score	24.0 ± 7.5	28.1 ± 7.3	<0.001
SOFA score	10.8 ± 3.7	14.2 ± 3.1	<0.001
Charlson comorbidity score	12.9 ± 2.3	13.1 ± 2.0	0.347
RIFLE criteria (%)^a
Risk	48 (51.1)	81 (42.2)	0.345
Injury	23 (24.5)	59 (30.7)
Failure	23 (24.5)	52 (27.1)
Comorbid diseases (%)
Hypertension	46 (48.9)	65 (33.9)	0.014
Diabetes mellitus	40 (42.6)	58 (30.2)	0.039
Biochemical data
DNI (%)	3.95 (2.35–9.10)	8.35 (3.23–24.73)	<0.001^b
Hemoglobin (g/dL)	10.5 ± 8.7	9.2 ± 2.2	0.063
WBC (10³/mm³)	13.9 (8.9–20.3)	10.6 (4.0–17.5)	0.009^b
Platelet (10³/ mm³)	114 (57–204)	80 (44–129)	0.002^b
eGFR (mL/min/1.73 m²)	76.7 ± 32.5	80.4 ± 29.2	0.404
Cholesterol (mg/dL)	98.1 ± 50.5	90.9 ± 46.5	0.271
Albumin (g/dL)	2.8 ± 0.7	2.6 ± 0.6	0.013
hs-CRP (mg/L)	106.0 (49.7–205.5)	102.6 (26.7–198.0)	0.581^b
Total bilirubin (mg/dL)	1.4 (0.6–3.0)	1.9 (0.7–4.5)	0.101^b
PT (INR)	1.5 ± 0.6	1.7 ± 0.8	0.007
aPTT (sec)	40.4 ± 14.6	53.1 ± 31.9	<0.001

Abbreviations: MAP mean arterial pressure, APACHE Acute Physiology and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment, DM diabetes mellitus, DNI delta neutrophil index, WBC white blood cells, Cr creatinine, eGFR estimated glomerular filtration rate, hs-CRP high sensitivity C-reactive protein, PT prothrombin time, aPTT activated partial thromboplastin time, ICU intensive care unit
^aAt ICU hospitalization; ^bMann-Whitney U-test

ISSN: 1471-2369