Hyperuricemia after orthotopic liver transplantation: divergent associations with progression of renal disease, incident end-stage renal disease, and mortality

Table 3 Crude mortality rates and adjusted relative hazard of death after liver transplantation, according to mean uric acid level in the first quarter after transplantation, and stratified by mean eGFR level

	Deaths	Person- years	Crude mortality rate ^a		Adjusted ^b relative hazard of death
Characteristic	Deaths	Person- years	Crude mortality rate ^a	p-value	HR	[95% C.I.]	p-value
All Patients (n = 304)				0.04
Uric Acid <6.5 mg/dl	36	905	39.8		1.0	Reference
Uric Acid ≥6.5 mg/dl	53	914	58.0		1.4	[0.9, 2.2]	0.11
Uric Acid (+1 mg/dl increase)					1.07	[0.97, 1.18]	0.16
Stratified analysis
eGFR ≥ 60 mg/min/1.73 m² (n = 204)				0.46
Uric Acid <6.5 mg/dl	33	750	44.0		1.0	Reference
Uric Acid ≥6.5 mg/dl	24	530	45.2		1.0 ^c	[0.6, 1.7]	0.95
Uric Acid (+1 mg/dl increase)					0.9 ^d	[0.8, 1.1]	0.36
eGFR < 60 mg/min/1.73 m² (n = 100)				0.005
Uric Acid <6.5 mg/dl	3	155	19.3		1.0	Reference
Uric Acid ≥6.5 mg/dl	29	383	75.6		3.7 ^c	[1.1, 12.0]	0.03
Uric Acid (+1 mg/dl increase)					1.2 ^d	[1.1, 1.4]	0.008

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