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Table 3 Outcomes of interest in the e-nephro study

From: Cost-effectiveness of home telemonitoring in chronic kidney disease patients at different stages by a pragmatic randomized controlled trial (eNephro): rationale and study design

Populations Outcomes of interest
Primary outcome of interest
 Population 1 Cost-result ratio, where result is achievement of blood pressure (systolic ≤ 130 and diastolic ≤ 80 mmHg) and proteinuria (≤0.5 g/24 h or proteinuria/creatininuria ≤ 50 mg/mmol) recommended targets at V3 [33].
 Populations 2 and 3 Cost-result ratio, where result is the cumulative number of days of acute-care hospitalisation over the 1-year study period (from V1 to V3).
Secondary outcomes of interest
 Populations 1, 2, and 3 Medication compliance measured by the French questionnaire by Girerd [34]
Anxiety/depression level, measured with the Hospitalization Anxiety Depression Scale (HADS) [35, 36]
Quality-of-life, measured with the KDQoL V36 questionnaire [37] for populations 1, 2 and the ReTransQoL questionnaire [38] for population 3
 Intervention group of populations 1, 2, and 3 + healthcare practio-ners Acceptability of the telemedicine system, measured with the French version of the Service User Technology Acceptability Questionnaire (WSD SUTAQ) for telemonitoring projects [39, 40].
The patient dropout rate from the telemedicine system will also be considered an indicator of the patient acceptability.
 Populations 1 and 3 1-year change in glomerular filtration rate measured with the MDRD formula [41]
 Population 3 Number of planned nephrology outpatient visits actually performed, and the number of unplanned visits and hospitalisations over the 1-year study period
 Population 2 Event-free survival at 1 year, an event being defined here as return to in-centre dialysis or hospitalisation
  Anaemia control, defined as achievement of haemoglobin, ferritin and coefficient of transferrin saturation recommended targets