Table 3 Comparative diagnostic performance of renal biomarkers in predicting death in paraquat poisoning stratified by albuminuria
From: Nephrotoxicity-induced proteinuria increases biomarker diagnostic thresholds in acute kidney injury
All patients (n = 50) | Patients with albuminuria (n = 34) a | p ‡ | |||||||
|---|---|---|---|---|---|---|---|---|---|
Biomarkers (ng/mg Cr) | AUC-ROC (95% CI) | Cut-off | Sensitivity (95% CI) | Specificity (95% CI) | AUC-ROC (95% CI) | Cutoff | Sensitivity (95% CI) | Specificity (95% CI) | Â |
uCysC | 0.78 (0.62–0.94) | >200 | 67 (35–90) | 67 (50–82) | 0.68 (0.49–0.88) | >300 | 67 (35–90) | 66 (43–84) | 0.46 |
uClu | 0.70 (0.52–0.87) | >750 | 67 (34–90) | 60 (42–75) | 0.55 (0.34–0.76) | >1600 | 58 (28–74) | 59 (36–80) | 0.29 |
Uβ2M | 0.68 (0.48–0.88) | >990 | 67 (35–90) | 68 (50–82) | 0.60 (0.39–0.82) | >1280 | 67 (35–90) | 68 (45–86) | 0.62 |
uNGAL | 0.81 (0.67–0.95) | >80 | 67 (35–90) | 68 (50–82) | 0.75 (0.56–0.93) | >90 | 67 (35–90) | 68 (45–86) | 0.60 |
uKIM-1 | 0.75 (0.57–0.90) | >0.96 | 75 (43–94) | 73 (56–85) | 0.61 (0.41–0.82) | >1.3 | 67 (35–90) | 40–83) | 0.38 |
uTFF3 | 0.85 (0.72–0.98) | >2340 | 75 (43–94) | 71 (52–85) | 0.82 (0.67–0.97) | >2830 | 75 (43–94) | 70 (46–88) | 0.74 |
uOstP | 0.82 (0.68–0.97) | >1760 | 75 (42–94) | 70 (53–84) | 75 (57–94) | >2100 | 75 (42–94) | 68 (45–86) | 0.60 |
uIL-18 (pg/mg Cr) | 64 (45–82) | >130 | 63 (31–89) | 60 (42–75) | 55 (34–76) | >130 | 63 (31–89) | 50 (28–72) | 0.54 |